Efficacy of long-term administration of isosorbide for Ménière's disease.

  title={Efficacy of long-term administration of isosorbide for M{\'e}ni{\`e}re's disease.},
  author={Izuru Nozawa and Hitoshi Nakayama and K Hashimoto and Shun-ichi Imamura and Kazufumi Hisamatu and Yoshihiko Murakami},
  journal={ORL; journal for oto-rhino-laryngology and its related specialties},
  volume={57 3},
The long-term therapeutic efficacy of isosorbide, an oral hyperosmotic diuretic, was clinically evaluated in 30 patients (14 males and 16 females) who were followed up in our clinic for more than 2 years. The patients ranged in age from 14 to 73 years, with a mean age of 49.2 years. Isosorbide was given orally, continuously or intermittently, for 27-297 weeks, depending on each patient's condition. The efficacy of the drug was determined according to the evaluation criteria of the American… CONTINUE READING