Efficacy of linaclotide for patients with chronic constipation.

BACKGROUND & AIMS Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase-C receptor that stimulates intestinal fluid secretion and transit and reduces pain in animal models. We assessed the safety and efficacy of a range of linaclotide doses in patients with chronic constipation. METHODS We performed a multicenter, double-blind… CONTINUE READING