Efficacy of irinotecan single drug treatment in children with refractory or recurrent hepatoblastoma--a phase II trial of the childhood liver tumour strategy group (SIOPEL).

@article{Zsros2012EfficacyOI,
  title={Efficacy of irinotecan single drug treatment in children with refractory or recurrent hepatoblastoma--a phase II trial of the childhood liver tumour strategy group (SIOPEL).},
  author={J{\'o}zsef Zs{\'i}ros and Laurence Brugi{\`e}res and Penelope Brock and Derek J. Roebuck and Rudolf Maibach and Margaret Child and Bruce Morland and Michela Casanova and Dani{\`e}le M. Pariente and Claudia Paris and Beatriz de Camargo and Milind D. Ronghe and Arthur Zimmermann and Jack Plaschkes and Piotr Czauderna and Giorgio Perilongo},
  journal={European journal of cancer},
  year={2012},
  volume={48 18},
  pages={
          3456-64
        }
}
PURPOSE To assess the clinical activity of irinotecan as single drug in children with refractory or recurrent hepatoblastoma. PATIENTS AND METHODS Four cycles of irinotecan were administered (20mg/m(2)/day intravenous (i.v.) infusion on days 1-5 and 8-12, every 21days) unless tumour progression occurred or resectability was achieved earlier. Tumour response was assessed according to modified SIOPEL and Response Evaluation Criteria In Solid Tumours (RECIST) criteria. Main end-points were best… CONTINUE READING
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