Efficacy of intralesional immunotherapy for the treatment of warts: A review of the literature

@article{Aldahan2016EfficacyOI,
  title={Efficacy of intralesional immunotherapy for the treatment of warts: A review of the literature},
  author={A. Aldahan and S. Mlacker and V. Shah and P. Kamath and M. Alsaidan and Sahal J Samarkandy and K. Nouri},
  journal={Dermatologic Therapy},
  year={2016},
  volume={29}
}
Warts are common epidermal growths caused by human papillomavirus that often cause significant discomfort and embarrassment. Current treatment options include topical therapies, cryotherapy, laser vaporization, and surgical excision. Many of these options are destructive and may result in scarring, while less aggressive approaches can lead to lesion recurrence. Additionally, these local modalities are not practical for patients with a large number of warts. Systemic approaches such as… Expand
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References

SHOWING 1-10 OF 55 REFERENCES
Intralesional immunotherapy with killed Mycobacterium indicus pranii vaccine for the treatment of extensive cutaneous warts.
TLDR
Killed Mw vaccine is safe and effective in the treatment of extensive cutaneous warts and larger, preferably randomized controlled trials are needed to assess its efficacy vis a vis standard therapies for warts. Expand
Intralesional immunotherapy for difficult to treat warts with Mycobacterium w vaccine
TLDR
This study provides new insight into the dose and schedule of treatment of this evolving therapeutic modality for the treatment of warts and eliminates the complications due to the sensitisation dose. Expand
Imiquimod in the Treatment of Cutaneous Warts: An Evidence-Based Review
TLDR
There have been several studies demonstrating the successful use of imiquimod to treat recalcitrant cutaneous warts, either alone or as combination therapy, however, these studies are limited in number, include small populations, and are non-controlled. Expand
Intralesional injection of mumps or Candida skin test antigens: a novel immunotherapy for warts.
TLDR
Observation of clearing of anatomically distinct and distant warts suggests acquisition of human papillomavirus-directed immunity in some patients, and intralesional injection of mumps or Candida antigens into warts of immune individuals represents effective treatment. Expand
Intralesional immunotherapy of warts with mumps, Candida, and Trichophyton skin test antigens: a single-blinded, randomized, and controlled trial.
TLDR
Intralesional immunotherapy using injection of Candida, mumps, or Trichophyton skin test antigens is an effective treatment for warts, as indicated by significantly higher response rates and distant response rates in subjects receiving antigen. Expand
Intralesional Antigen Immunotherapy for the Treatment of Warts: Current Concepts and Future Prospects
TLDR
Intralesional antigen immunotherapy seems to be a promising, effective and safe treatment modality for viral warts, and future well-designed and controlled studies would help to more clearly define its place in the challenging field of wart therapy. Expand
Immunotherapy with Intralesional Candida Albicans Antigen in Resistant or Recurrent Warts: A Study
TLDR
Intralesional Candida immunotherapy seems to be an effective treatment option in more than half of the patients who fail to show a positive response to destructive modes of treatment or in whom there are multiple recurrences. Expand
Intralesional immunotherapy for warts using a combination of skin test antigens: a safe and effective therapy.
TLDR
Whether injection of the combination of Candida albicans, mumps, and Trichophyton skin test antigens was more efficacious than and as safe as single antigen injection was determined. Expand
Immunotherapy for Recalcitrant Warts in Children Using Intralesional Mumps or Candida Antigens
TLDR
It is concluded that intralesional injection of skin test antigens is an effective therapy for children who have recalcitrant, nongenital, cutaneous warts. Expand
Treatment of recalcitrant warts with Bacillus Calmette–Guérin: a promising new approach
TLDR
Intralesional immunotherapy with BCG vaccine seems to be a promising effective and safe treatment modality for recalcitrant warts in a 48‐year‐old male who presented with troublesome huge common wart on the left little toe of 5 years duration. Expand
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