Efficacy of injectable trivalent virosomal-adjuvanted inactivated influenza vaccine in preventing acute otitis media in children with recurrent complicated or noncomplicated acute otitis media.

@article{Marchisio2009EfficacyOI,
  title={Efficacy of injectable trivalent virosomal-adjuvanted inactivated influenza vaccine in preventing acute otitis media in children with recurrent complicated or noncomplicated acute otitis media.},
  author={Paola Marchisio and Susanna Esposito and Sonia Bianchini and Elisa Dusi and Michela Fusi and Erica Nazzari and Raffaella Picchi and Carlotta Galeone and Nicola Principi},
  journal={The Pediatric infectious disease journal},
  year={2009},
  volume={28 10},
  pages={
          855-9
        }
}
BACKGROUND Most cases of acute otitis media (AOM) follow an upper respiratory infection due to viruses, including influenza viruses. As effective and safe influenza vaccines are available, their use has been considered among the possible measures of AOM prophylaxis. OBJECTIVES To evaluate the efficacy of an inactivated virosomal-adjuvanted influenza vaccine in preventing AOM in children with a history of noncomplicated recurrent AOM (rAOM) or rAOM complicated by spontaneous perforation… CONTINUE READING

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