Efficacy of immunoliposomes on cancer models in a cell-surface-antigen-density-dependent manner

@article{Hosokawa2003EfficacyOI,
  title={Efficacy of immunoliposomes on cancer models in a cell-surface-antigen-density-dependent manner},
  author={Saiko Hosokawa and Toshiaki Tagawa and Hisae Niki and Yoko Hirakawa and Katsuhiko Nohga and Kazuhiro Nagaike},
  journal={British Journal of Cancer},
  year={2003},
  volume={89},
  pages={1545 - 1551}
}
We have recently established a cancer-reactive human monoclonal antibody, GAH, with a positive ratio of over 90% against stomach cancer. GAH was formulated as polyethyleneglycol (PEG)-modified immunoliposomal doxorubicin (DXR) (ILD) and its efficacy was examined against gastrointestinal human cancers. In in vitro studies, a comparison of ILD with PEG-modified liposomal DXR (LD) demonstrated that ILD had dose-dependent cytotoxicity for GAH-reactive B37 cancer cells, but not LD. In concordance… CONTINUE READING

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