Efficacy of human simulated exposures of ceftaroline against phenotypically diverse Enterobacteriaceae isolates.

@article{Housman2012EfficacyOH,
  title={Efficacy of human simulated exposures of ceftaroline against phenotypically diverse Enterobacteriaceae isolates.},
  author={Seth T. Housman and Rebecca A Keel and Jared L. Crandon and Gregory Williams and David P Nicolau},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 5},
  pages={2576-80}
}
Ceftaroline fosamil, a new broad-spectrum cephalosporin, exhibits potent bactericidal activity against common Gram-negative pathogens, including Enterobacteriaceae, and Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae. The purpose of this study was to evaluate the efficacy of a human simulated dose of ceftaroline fosamil against clinical Enterobacteriaceae in both neutropenic and immunocompetent mouse thigh… CONTINUE READING