Efficacy of high-dose versus standard-dose influenza vaccine in older adults.

@article{Diazgranados2014EfficacyOH,
  title={Efficacy of high-dose versus standard-dose influenza vaccine in older adults.},
  author={Carlos A Diazgranados and Andrew J Dunning and Murray Kimmel and Daniel Kirby and John T Treanor and Avi Collins and Richard A Pollak and Janet Christoff and John W. Earl and Victoria A Landolfi and Earl Martin and Sanjay Gurunathan and Richard Nathan and David P. Greenberg and Nadia G. Tornieporth and Michael D. Decker and H. Keipp B. Talbot},
  journal={The New England journal of medicine},
  year={2014},
  volume={371 7},
  pages={
          635-45
        }
}
BACKGROUND As compared with a standard-dose vaccine, a high-dose, trivalent, inactivated influenza vaccine (IIV3-HD) improves antibody responses to influenza among adults 65 years of age or older. This study evaluated whether IIV3-HD also improves protection against laboratory-confirmed influenza illness. METHODS We conducted a phase IIIb-IV, multicenter, randomized, double-blind, active-controlled trial to compare IIV3-HD (60 μg of hemagglutinin per strain) with standard-dose trivalent… 

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