Efficacy of high-dose versus standard-dose influenza vaccine in older adults.
@article{Diazgranados2014EfficacyOH, title={Efficacy of high-dose versus standard-dose influenza vaccine in older adults.}, author={Carlos A Diazgranados and Andrew J Dunning and Murray Kimmel and Daniel Kirby and John T Treanor and Avi Collins and Richard A Pollak and Janet Christoff and John W. Earl and Victoria A Landolfi and Earl Martin and Sanjay Gurunathan and Richard Nathan and David P. Greenberg and Nadia G. Tornieporth and Michael D. Decker and H. Keipp B. Talbot}, journal={The New England journal of medicine}, year={2014}, volume={371 7}, pages={ 635-45 } }
BACKGROUND
As compared with a standard-dose vaccine, a high-dose, trivalent, inactivated influenza vaccine (IIV3-HD) improves antibody responses to influenza among adults 65 years of age or older. This study evaluated whether IIV3-HD also improves protection against laboratory-confirmed influenza illness.
METHODS
We conducted a phase IIIb-IV, multicenter, randomized, double-blind, active-controlled trial to compare IIV3-HD (60 μg of hemagglutinin per strain) with standard-dose trivalent…
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References
SHOWING 1-10 OF 42 REFERENCES
High-dose trivalent influenza vaccine compared to standard dose vaccine in elderly adults: safety, immunogenicity and relative efficacy during the 2009-2010 season.
- Medicine, BiologyVaccine
- 2013
Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older.
- MedicineThe Journal of infectious diseases
- 2009
The results suggest that the high-dose vaccine may provide improved protective benefits for older adults, and there was a statistically significant increase in the level of antibody response induced by HD influenza vaccine, compared with that induced by SD vaccine.
Immunogenicity and safety of Fluzone(®) intradermal and high-dose influenza vaccines in older adults ≥65 years of age: a randomized, controlled, phase II trial.
- MedicineVaccine
- 2014
Efficacy and safety of a live attenuated influenza vaccine in adults 60 years of age and older.
- MedicineVaccine
- 2009
Effectiveness of Adjuvanted Influenza Vaccination in Elderly Subjects in Northern Italy
- MedicineAmerican journal of epidemiology
- 2012
Risk of hospitalization for influenza or pneumonia was 25% lower for ATIV relative to TIV, and ATIV is likely to be even more protective than this result suggests.
The efficacy of influenza vaccination in elderly individuals. A randomized double-blind placebo-controlled trial.
- MedicineJAMA
- 1994
In the elderly, influenza vaccination may halve the incidence of serological and clinical influenza (in periods of antigenic drift), which is less pronounced for self-reported influenza.
AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial.
- MedicineThe Lancet. Infectious diseases
- 2013
The Efficacy of Influenza Vaccine in Elderly Persons
- MedicineAnnals of Internal Medicine
- 1995
The meta-analysis confirms the findings of several recent studies on the effectiveness of influenza vaccination in elderly persons and should heighten physician awareness and encourage the universal annual use of influenza vaccine in elderly Persons.
Seasonal influenza vaccine efficacy and its determinants in children and non-elderly adults: a systematic review with meta-analyses of controlled trials.
- Medicine, BiologyVaccine
- 2012
Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis.
- MedicineThe Lancet. Infectious diseases
- 2012