• DOI:10.1056/NEJMoa1315727
Corpus ID: 205096393

Efficacy of high-dose versus standard-dose influenza vaccine in older adults.

@article{Diazgranados2014EfficacyOH,
  title={Efficacy of high-dose versus standard-dose influenza vaccine in older adults.},
  author={C. Diazgranados and A. Dunning and M. Kimmel and D. Kirby and J. Treanor and Avi Collins and R. Pollak and Janet Christoff and John Earl and Victoria A Landolfi and E. Martin and S. Gurunathan and Richard Nathan and D. Greenberg and Nadia G. Tornieporth and M. Decker and H. Talbot},
  journal={The New England journal of medicine},
  year={2014},
  volume={371 7},
  pages={
          635-45
        }
}

C. Diazgranados, A. Dunning, +14 authors H. Talbot

Published 2014

Medicine

The New England journal of medicine

BACKGROUND As compared with a standard-dose vaccine, a high-dose, trivalent, inactivated influenza vaccine (IIV3-HD) improves antibody responses to influenza among adults 65 years of age or older. This study evaluated whether IIV3-HD also improves protection against laboratory-confirmed influenza illness. METHODS We conducted a phase IIIb-IV, multicenter, randomized, double-blind, active-controlled trial to compare IIV3-HD (60 μg of hemagglutinin per strain) with standard-dose trivalent… CONTINUE READING

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