Efficacy of folic acid supplementation in stroke prevention: a meta-analysis

@article{Wang2007EfficacyOF,
  title={Efficacy of folic acid supplementation in stroke prevention: a meta-analysis},
  author={Xiaobin Wang and X. Qin and H. Demirtas and Jianping Li and G. Mao and Y. Huo and N. Sun and Lisheng Liu and Xiping Xu},
  journal={The Lancet},
  year={2007},
  volume={369},
  pages={1876-1882}
}
BACKGROUND The efficacy of treatments that lower homocysteine concentrations in reducing the risk of cardiovascular disease remains controversial. [...] Key MethodMETHODS We collected data from eight randomised trials of folic acid that had stroke reported as one of the endpoints. Relative risk (RR) was used as a measure of the effect of folic acid supplementation on the risk of stroke with a random effect model. The analysis was further stratified by factors that could affect the treatment effects. Expand
Efficacy of Homocysteine-Lowering Therapy With Folic Acid in Stroke Prevention: A Meta-Analysis
TLDR
Folic acid supplementation did not demonstrate a major effect in averting stroke, however, potential mild benefits in primary stroke prevention, especially when folate is combined with B vitamins and in male patients, merit further investigation. Expand
Folic Acid Supplementation for Stroke Prevention in Patients With Cardiovascular Disease
TLDR
It is demonstrated that folic acid supplementation is effective in stroke prevention in patients with CVD through a meta‐analysis of randomized clinical trials. Expand
Meta-analysis of folic acid efficacy trials in stroke prevention
TLDR
Folic acid supplementation could reduce the stroke risk in regions without folic Acid fortification, particularly in trials using a relatively low dosage of folic acid and with low vitamin B12 levels. Expand
Effect of B-vitamin Supplementation on Stroke: a Meta-Analysis of Randomized Controlled Trials
TLDR
This study indicates that B-vitamin supplementation is not associated with a lower risk of stroke based on relative and absolute measures of association. Expand
Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta‐Analysis of Randomized Controlled Trials
TLDR
A greater benefit for CVD was observed among participants with lower plasma folate levels and without preexisting CVD and in studies with larger decreases in homocysteine levels, while folic acid supplementation had no significant effect on risk of coronary heart disease. Expand
Effect of Folic Acid Supplementation on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
TLDR
Folic acid supplementation does not effect on the incidence of major cardiovascular events, stroke, myocardial infarction or all cause mortality. Expand
A Meta-Analysis of Folic Acid in Combination with Anti-Hypertension Drugs in Patients with Hypertension and Hyperhomocysteinemia
TLDR
Findings indicated that folic acid supplementation was effective in the primary prevention of CVCE among HT/HHcy patients, as well as reducing the blood pressure and total homocysteine levels. Expand
Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels.
TLDR
Analysis of within-trial results stratified by baseline homocysteine suggests potential harm in those with high homocy steine at baseline, and FA supplementation should not be recommended as a means to prevent or treat CVD or stroke. Expand
The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: a randomized, placebo-controlled trial.
TLDR
Folic acid supplementation results in significant IMT reduction after 18 months in patients with at least one cardiovascular risk factor, and homocysteine levels were significantly reduced in the active treatment group compared to a non-significant increase in the placebo group. Expand
Effect of folic acid supplementation on the progression of carotid intima-media thickness: a meta-analysis of randomized controlled trials.
TLDR
It is indicated that folic acid supplementation is effective in reducing the progression of CIMT, particularly in subjects with CKD or high CVD risk and among trials with higher baseline CimT levels or a larger homocysteine reduction. Expand
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