Efficacy of fluconazole prophylaxis for prevention of invasive fungal infection in extremely low birth weight infants.

@article{Aziz2010EfficacyOF,
  title={Efficacy of fluconazole prophylaxis for prevention of invasive fungal infection in extremely low birth weight infants.},
  author={Mariam S Aziz and Aloka L. Patel and Jennifer Losavio and Anjali Iyengar and Michael D Berven and Nathan J. Schloemer and Andrew Jakubowicz and Tina Mathai and James B McAuley},
  journal={The Pediatric infectious disease journal},
  year={2010},
  volume={29 4},
  pages={352-6}
}
BACKGROUND Invasive fungal infections (IFI) are an important cause of late-onset disease in extremely low birth weight (ELBW) infants. Despite prior trials of fluconazole prophylaxis in neonates, application of this regimen remains controversial. Review of our neonatal intensive care unit aggregate annual number of fungal isolates from sterile sites in ELBW infants from 1997 to 2006 suggested a significant decrease following the institution of routine prophylactic fluconazole in February 2002… CONTINUE READING