Efficacy of felbamate monotherapy in patients undergoing presurgical evaluation of partial seizures

@article{Devinsky1995EfficacyOF,
  title={Efficacy of felbamate monotherapy in patients undergoing presurgical evaluation of partial seizures},
  author={Orrin Devinsky and R. Faught and B. Joe Wilder and Andres M. Kanner and Marc Kamin and Lynn D. Kramer and A. Rosenberg},
  journal={Epilepsy Research},
  year={1995},
  volume={20},
  pages={241-246}
}

Oxcarbazepine: double-blind, randomized, placebo-control, monotherapy trial for partial seizures.

TLDR
Results demonstrate that oxcarbazepine given as monotherapy is effective and safe for the treatment of partial seizures in this paradigm.

Efficacy of felbamate in the treatment of intractable pediatric epilepsy.

Oxcarbazepine (Trileptal) as monotherapy in patients with partial seizures

TLDR
This trial demonstrated that OXC at 2400 mg/day is well tolerated and efficacious when administered as monotherapy in patients with uncontrolled partial onset seizures.

Oxcarbazepine monotherapy for partial-onset seizures

TLDR
OXC is safe and effective in the treatment of patients with partial epilepsy previously receiving treatment with other antiepileptic drugs, and the results of this trial are consistent with previous monotherapy trials with OXC.

Felbamate as an add-on therapy for refractory epilepsy.

TLDR
No reliable evidence is found to support the use of felbamate as an add-on therapy in patients with refractory partial-onset epilepsy, and a large scale, randomized controlled trial conducted over a greater period of time is required to inform clinical practice.

Gabapentin monotherapy: I. An 8-day, double-blind, dose controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures

TLDR
It is demonstrated that gabapentin has anticonvulsant activity and is well tolerated when administered as monotherapy in patients with refractory partial seizures in patients whose antiepileptic medications had been discontinued for seizure monitoring.

Monotherapy trials: presurgical studies

  • G. Pledger
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    Epilepsy Research
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Evaluation of drug treatment outcome in epilepsy: a clinical perspectiv

  • E. Perucca
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    Pharmacy World and Science
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TLDR
Clinical outcome measures used in trials aimed at assessing the efficacy and safety of antiepileptic drugs, including retention of patients on the allocated treatment over time, are discussed.
...

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TLDR
The ability of felbamate to quickly and safely reduce the occurrence of frequent partial-onset seizures and maintain effective seizure control following reductions in the dosages of standard antiepileptic drugs is demonstrated.

Felbamate monotherapy: Controlled trial in patients with partial onset seizures

TLDR
FBM monotherapy was effective in the treatment of partial onset seizures with or without generalization and demonstrated a favorable safety profile.

Felbamate monotherapy for partial‐onset seizures

TLDR
FBM monotherapy was effective in the treatment of partial-onset seizures with or without secondarily generalized seizures and demonstrated a favorable safety profile.

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TLDR
Two trial designs are described: a placebo‐ control design with inpatients who in undergoing a presurgery seizure evaluation have had all antiepileptic drugs discontinued; and an active‐control design aimed at showing the test drug superior to the control treatment, thus avoiding the interpretational difficulties of no‐difference outcomes.

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Predictors of poor outcome are not necessarily the converse of predictors of good outcome, but identification of such factors is important to allow earlier referral of patients destined to meet criteria for intractable to allow alternative therapies to be instituted.

The natural history of drug resistant epilepsy: epidemiologic considerations.

TLDR
Predictors of poor outcome are not necessarily the converse of predictors of good outcome, but identification of such factors is important to allow earlier referral of patients destined to meet criteria for intractable to allow alternative therapies to be instituted.

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A seizure- free patient should be the goal of both medical and surgical therapy, and the outcomes of both should be presented so that the proportion of patients totally seizure-free (and not just with major improvement) can be determined.

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