Efficacy of experimental treatments compared with standard treatments in non-inferiority trials: a meta-analysis of randomized controlled trials.

@article{Soonawala2010EfficacyOE,
  title={Efficacy of experimental treatments compared with standard treatments in non-inferiority trials: a meta-analysis of randomized controlled trials.},
  author={Darius Soonawala and Rutger A Middelburg and Matthias Egger and Jan P. Vandenbroucke and Olaf Matthijs Dekkers},
  journal={International journal of epidemiology},
  year={2010},
  volume={39 6},
  pages={1567-81}
}
BACKGROUND There is concern that non-inferiority trials might be deliberately designed to conceal that a new treatment is less effective than a standard treatment. In order to test this hypothesis we performed a meta-analysis of non-inferiority trials to assess the average effect of experimental treatments compared with standard treatments. METHODS One hundred and seventy non-inferiority treatment trials published in 121 core clinical journals were included. The trials were identified through… CONTINUE READING
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