Efficacy of epicutaneous Diractin® (ketoprofen in Transfersome® gel) for the treatment of pain related to eccentric muscle contractions

@inproceedings{Rother2009EfficacyOE,
  title={Efficacy of epicutaneous Diractin® (ketoprofen in Transfersome® gel) for the treatment of pain related to eccentric muscle contractions},
  author={Matthias Rother and Egbert J. Seidel and Priscilla M. Clarkson and Stefan Mazgareanu and Ulrich Vierl and Ilka Rother},
  booktitle={Drug design, development and therapy},
  year={2009}
}
OBJECTIVE To investigate the effect of epicutaneously applied Diractin (ketoprofen in Transfersome gel) on pain induced by eccentric muscle contractions. METHODS Three pilot studies which were subsequently pooled for a meta-analysis compared the efficacy of a single application of 25 mg ketoprofen in Diractin to 25 mg oral ketoprofen and placebo for the treatment of pain induced by 50 eccentric contractions of the elbow flexor muscles. In addition, the effect of multiple usage of up to 100 mg… CONTINUE READING

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