Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia

  title={Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia},
  author={Adriano Lazzarin and Bonaventura Clotet and David Cooper and J. Reynes and Keikawus Arast{\'e}h and Mark Nelson and Christine Katlama and Hans-J{\"u}rgen Stellbrink and J F Delfraissy and Josephus H. M. Lange and Les Huson and Ralph Demasi and Cynthia Wat and John T. Delehanty and Claude Drobnes and Miklos P Salgo},
  journal={The New England journal of medicine},
  volume={348 22},
BACKGROUND The T-20 vs. Optimized Regimen Only Study 2 (TORO 2) compared the efficacy and safety of 24 weeks of treatment with the fusion inhibitor enfuvirtide in combination with an optimized background antiretroviral regimen with the efficacy and safety of the optimized background regimen alone. METHODS The patients had previous treatment with each of the three classes of antiretroviral drugs, documented resistance to each class, or both and a plasma level of human immunodeficiency virus… CONTINUE READING
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