Efficacy of duloxetine on cognition, depression, and pain in elderly patients with major depressive disorder: an 8-week, double-blind, placebo-controlled trial.

@article{Raskin2007EfficacyOD,
  title={Efficacy of duloxetine on cognition, depression, and pain in elderly patients with major depressive disorder: an 8-week, double-blind, placebo-controlled trial.},
  author={Joel Raskin and Curtis G. Wiltse and Alan P Siegal and Javaid l. Sheikh and Jimmy Xu and James J Dinkel and Benjamin T. Rotz and Richard C. Mohs},
  journal={The American journal of psychiatry},
  year={2007},
  volume={164 6},
  pages={900-9}
}
OBJECTIVE This study compared the effects of duloxetine, 60 mg/day, versus placebo on cognition, depression, and pain in elderly patients with recurrent major depressive disorder. METHOD Patients were randomly assigned (2:1) to duloxetine, 60 mg/day (N=207), or placebo (N=104) for 8 weeks in a double-blind study. The primary outcome measure was a prespecified composite cognitive score composed of four individual tests. Secondary measures included the Geriatric Depression Scale, the Hamilton… CONTINUE READING
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