Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.

@article{Iyengar2004EfficacyOD,
  title={Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.},
  author={Smriti Iyengar and Amy A Webster and Susan K. Hemrick-Luecke and Jimmy Yu Xu and Rosa Maria A. Simmons},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={311 2},
  pages={
          576-84
        }
}
5-Hydroxytryptamine (serotonin) (5-HT) and norepinephrine (NE) are implicated in modulating descending inhibitory pain pathways in the central nervous system. Duloxetine is a selective and potent dual 5-HT and NE reuptake inhibitor (SNRI). The ability of duloxetine to antagonize 5-HT depletion in para-chloramphetamine-treated rats was comparable with that of paroxetine, a selective serotonin reuptake inhibitor (SSRI), whereas its ability to antagonize NE depletion in alpha-methyl-m-tyrosine… CONTINUE READING

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