Efficacy of doxycycline and ciprofloxacin against experimental Yersinia pestis infection.

@article{Russell1998EfficacyOD,
  title={Efficacy of doxycycline and ciprofloxacin against experimental Yersinia pestis infection.},
  author={Paul F. Russell and Stephen M. Eley and Michael Green and Anthony J. Stagg and Rosalind M. Taylor and David D. Nelson and Richard J Beedham and David L. Bell and Debbie Rogers and Doug Whittington and Richard W. Titball},
  journal={The Journal of antimicrobial chemotherapy},
  year={1998},
  volume={41 2},
  pages={
          301-5
        }
}
The efficacies of ciprofloxacin and doxycycline prophylaxis and therapy were assessed against experimental pneumonic plague infections induced by two strains of Yersinia pestis in a mouse model. When exposed to an aerosol of Y. pestis strain GB, containing 8.39 x 10(5) +/- 4.17 x 10(4) cfu, the retained dose was 7.3 x 10(3) +/- 2.3 x 10(3) cfu. When exposed to an aerosol of Y. pestis strain CO-92, containing 1.86 x 10(5) +/- 7.4 x 10(3) cfu, the retained dose was 3.4 x 10(4) +/- 2.6 x 10(3) cfu… CONTINUE READING
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