Efficacy of dietary hempseed oil in patients with atopic dermatitis

  title={Efficacy of dietary hempseed oil in patients with atopic dermatitis},
  author={James C. Callaway and Ursula S Schwab and Ilkka T. Harvima and Pirjo M Halonen and Otto T. Mykk{\"a}nen and Pekka Hyv{\"o}nen and Tomi J{\"a}rvinen},
  journal={Journal of Dermatological Treatment},
  pages={87 - 94}
Background: Hempseed oil is a rich and balanced source of omega‐6 and omega‐3 polyunsaturated fatty acids (PUFAs). Anecdotal evidence indicated that dietary hempseed oil might be useful in treating symptoms of atopic dermatitis. Patients and methods: Dietary hempseed oil and olive oil were compared in a 20‐week randomized, single‐blind crossover study with atopic patients. Fatty acid profiles were measured in plasma triglyceride, cholesteryl and phospholipid fractions. A patient questionnaire… 
Effects of hempseed and flaxseed oils on the profile of serum lipids, serum total and lipoprotein lipid concentrations and haemostatic factors
The effects of HO and FO on the profile of serum lipids differed significantly, with only minor effects on concentrations of fasting serum total or lipoprotein lipids, and no significant changes in concentrations of plasma glucose or insulin or in haemostatic factors.
Evening primrose oil is effective in atopic dermatitis: a randomized placebo-controlled trial.
BACKGROUND Atopic dermatitis (AD) is a chronic, relapsing, itchy dermatosis of multifactorial origin, which commonly starts in childhood. Defective metabolism of essential fatty acids leading to
5 – Hempseed Oil
The objective of the work was to study the chemical content of a few vegetable oils and its correlation with their antioxidant activity following the use of oils in cosmetic and therapeutic purposes.
Effect of olive oil on the skin
α-Linolenic acid: nutraceutical, pharmacological and toxicological evaluation.
The Enigma of Bioactivity and Toxicity of Botanical Oils for Skin Care
This review contrasted the functionality of skin oils versus the differential biological and toxicological effects of major plant oils, and to correlate them to their compositional changes to promote awareness of health practitioners and botanical product manufacturers for the safety and efficacy of oil-based interventions based on their fatty acid profiles.
Fatty acid composition of hempseed oils from different locations in Turkey
The results show that hempseed grown in north-western Turkey provides a well balanced and rich source of dietary omega-6 and -3 essential fatty acids and appears to be a potentially valuable source of food.


Evening primrose oil (Efamol) in the treatment of children with atopic eczema.
After 4 weeks the eczema of essential fatty acid-treated children significantly improved in comparison with that of placebo- treated children, and there were significant changes in plasma fatty acid composition between the basal values and the end of active treatment, and between the placebo and actively treated children.
Evening primrose oil (Epogam) in the treatment of chronic hand dermatitis: disappointing therapeutic results.
The study indicates that the therapeutic value of orally administered GLA for chronic hand dermatitis is not superior to that of placebo, and electron-microscopic evaluation of the epidermal lipid bilayer could underline the efficacy of essential fatty acids in chronichand dermatitis.
Essential fatty acid metabolism and its modification in atopic eczema.
  • D. Horrobin
  • Medicine, Biology
    The American journal of clinical nutrition
  • 2000
In most but not all studies, administration of GLA has been found to improve the clinically assessed skin condition, the objectively assessed skin roughness, and the elevated blood catecholamine concentrations of patients with atopic eczema.
Hempseed as a nutritional resource: An overview
Hempseed has been used to treat various disorders for thousands of years in traditional oriental medicine, and recent clinical trials have identified hempseed oil as a functional food, and animal feeding studies demonstrate the long-standing utility of hempseed as an important food resource.
Effect of dietary supplementation with black currant seed oil on the immune response of healthy elderly subjects.
BCSO has a moderate immune-enhancing effect attributable to its ability to reduce prostaglandin E(2) production.
Essential fatty acids in breast milk of atopic mothers: comparison with non-atopic mothers, and effect of borage oil supplementation
It is concluded that atopy is related to a metabolic disturbance beyond the D6D enzymatic step and a low level of arachidonic acid in breast milk may be a risk factor for the development of atopy in the infant.
Gamma-linolenic acid supplementation for prophylaxis of atopic dermatitis--a randomized controlled trial in infants at high familial risk.
Early supplementation with GLA in children at high familial risk does not prevent the expression of atopy as reflected by total serum IgE, but it tends to alleviate the severity of atopic dermatitis in later infancy in these children.
Dietary fatty acids and allergy.
It is concluded that careful manipulation of dietary PUFAs may play a key role in the successful management of inflammation associated with atopic diseases.
Double‐blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema
No overall efficacy of GLA‐containing borage oil in atopic eczema is shown, with steroid use being the primary response parameter, although it suggests that a subgroup of patients may benefit from this well‐tolerated treatment.
Essential fatty acids in the plasma phospholipids of patients with atopic eczema.
The observations suggest that atopic eczema is associated not with any defect of EFA intake, but with abnormal metabolism, possibly involving the enzyme delta-6-desaturase.