Efficacy of dexmedetomidine in prevention of junctional ectopic tachycardia and acute kidney injury after pediatric cardiac surgery: A meta‐analysis

  title={Efficacy of dexmedetomidine in prevention of junctional ectopic tachycardia and acute kidney injury after pediatric cardiac surgery: A meta‐analysis},
  author={Xin Li and Chengxin Zhang and Di Dai and Haiyuan Liu and Shenglin Ge},
  journal={Congenital Heart Disease},
OBJECTIVE We conducted a meta-analysis to evaluate the effects of prophylactic perioperative dexmedetomidine administration on postoperative junctional ectopic tachycardia (JET) and acute kidney injury (AKI) in pediatric patients having undergone cardiac surgery. DESIGN This systematic review was registered with PROSPERO (CRD42017083880). Databases including PubMed, Cochrane Central Register of Controlled Trials, and Web of Science were searched for randomized controlled trials (RCTs) and… Expand

Paper Mentions

Interventional Clinical Trial
Aim 1: Primary Prevention of Post-operative Cardiac Arrhythmias 1. To evaluate the efficacy of dexmedetomidine vs. the combination of Magnesium Sulfate and… Expand
ConditionsCardiac; Dysrhythmia, Postoperative, Congenital Heart Surgery
Dexmedetomidine use in pediatric strabismus surgery: A systematic review and meta-analysis
In patients who have undergone pediatric strabismus surgery, dexmedetomidine use may alleviate EA, PONV, and postoperative pain and reduce OCR incidence. Expand
Renal-protective effect of dexmedetomidine during cardiac surgery with cardiopulmonary bypass: a prospective, randomized, double-blind, placebo-controlled study
Dexmedetomidine could have a protective role in renal function during cardiac surgery using the CPB, and Bradycardia developed more frequently in the dexmedetamidine group than in the placebo group. Expand
Use of dexmedetomidine in pediatric cardiac anesthesia
Due to a favorable mix of beneficial physiologic actions and a limited adverse effect profile, DEX is established in the perioperative pediatric cardiac surgery setting, however, evidence from high-quality randomized controlled trials on the effects of supplemental DEX on meaningful patient outcomes is scarce. Expand
Selected 2018 Highlights in Congenital Cardiac Anesthesia.
The patient with high-risk congenital heart disease (CHD) presenting for noncardiac surgery, cardiopulmonary resuscitation in infants and children with CHD, dexmedetomidine use in pediatric patients, point-of-care lung ultrasound, and regional anesthesia in pediatric cardiac surgery are considered noteworthy. Expand
Predicting the Risk of Acute Kidney Injury in Patients After Percutaneous Coronary Intervention (PCI) or Cardiopulmonary Bypass (CPB) Surgery: Development and Assessment of a Nomogram Prediction Model
  • Yi Du, Xiuzhe Wang, +4 authors Shu-Xian Chen
  • Medicine
  • Medical science monitor : international medical journal of experimental and clinical research
  • 2021
The prediction model was efficient in predicting the risk of AKI by incorporating ultrasound examinations and a number of factors, which included operation methods, age, congestive heart failure, body mass index, heart rate, white blood cell count, platelet count, hemoglobin, uric acid, and peak intensity. Expand
Strategies to Reduce Perioperative Nephrotoxicity.
This review outlines the possible strategies to reduce perioperative nephrotoxicity and the development of postoperative AKI. Expand
Junctional ectopic tachycardia in infants and children
A staged approach to therapy with improved pharmacological therapies and the use of catheter‐based therapies is discussed, also known as automatic junctional tachycardia and includes paroxysmal or non‐paroxys mal forms. Expand
Arrhythmias in Children and Patients with Congenital Heart Disease
Catheter ablation has largely supplanted pharmacologic therapy for supraventricular tachycardias in children older than about 5 years, with results comparable to those in adults, and risk of collateral damage to structures in the growing heart makes catheter Ablation less attractive as primary therapy in smaller children. Expand
Big Syringe, Little Syringe.


Dexmedetomidine prevents acute kidney injury after adult cardiac surgery: a meta-analysis of randomized controlled trials
Perioperative administration of dexmedetomidine in adult patients undergoing cardiac surgery may reduce the incidence of postoperative AKI and future trials are needed to determine the dose and timing in improving outcomes, especially in patients with decreased baseline kidney function. Expand
Effect of dexmeditomidine on postoperative junctional ectopic tachycardia after complete surgical repair of tetralogy of Fallot: A prospective randomized controlled study
Examination of possible preventive effects of dexmedetomidine on postoperative JET and its impact on the duration of ventilation time and length of Intensive Care Unit stay found it may have a potential benefit of preventing perioperativeJET. Expand
Efficacy of Prophylactic Dexmedetomidine in Preventing Postoperative Junctional Ectopic Tachycardia After Pediatric Cardiac Surgery
Prophylactic use of dexmedetomidine is associated with significantly decreased incidence of postoperative junctional ectopic tachycardia in children after congenital heart surgery without significant side effects. Expand
Preincision Initiation of Dexmedetomidine Maximally Reduces the Risk of Junctional Ectopic Tachycardia in Children Undergoing Ventricular Septal Defect Repairs.
Preincision initiation of DEX and its continued use during the immediate postoperative period are significantly associated with reduced risk of JET after congenital heart surgeries involving repair of ventricular septal defect. Expand
The efficacy of pre-emptive dexmedetomidine versus amiodarone in preventing postoperative junctional ectopic tachycardia in pediatric cardiac surgery
Perioperative use of dexmedetomidine and amiodarone is associated with significantly decreased incidence of JET as compared to placebo without significant side effects. Expand
Dexmedetomidine Is Associated With Lower Incidence of Acute Kidney Injury After Congenital Heart Surgery
The use of a dexmedetomidine infusion in pediatric patients after congenital heart surgery was associated with a decreased incidence of acute kidney injury; however, it was not associated with changes in clinical outcomes. Expand
Efficacy of dexmedetomidine for the control of junctional ectopic tachycardia after repair of tetralogy of Fallot
DEX had a therapeutic role in the prevention of junctional ectopic tachycardia in patients undergoing repair for TOF and was comparable between two groups before starting the drug but statistically significant after bypass until 08 hours after transferring the patient to ICU. Expand
Junctional ectopic tachycardia after surgery for congenital heart disease in children
JET occurred in approximately 10% of children following cardiac surgery and was associated with higher mortality and longer ICU stay and risk factors included high inotropic requirements after surgery and extensive myocardial injury in terms of high CK-MB values and longer CPB duration. Expand
The effect of intraoperative dexmedetomidine on acute kidney injury after pediatric congenital heart surgery
Intraoperative infusion of dexmedetomidine may reduce the incidence of AKI and suppress post-bypass eGFR decline. Expand
Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations.
Perioperative use of dexmedetomidine is associated with a significantly decreased incidence of ventricular and supraventricular tachyarrhythmias, without significant adverse effects. Expand