Efficacy of cryotherapy associated with laser therapy for decreasing severity of melphalan-induced oral mucositis during hematological stem-cell transplantation: a prospective clinical study.

@article{Eduardo2015EfficacyOC,
  title={Efficacy of cryotherapy associated with laser therapy for decreasing severity of melphalan-induced oral mucositis during hematological stem-cell transplantation: a prospective clinical study.},
  author={Fernanda de Paula Eduardo and Let{\'i}cia de Mello Bezinelli and Roberta Marques da Graça Lopes and Jairo Jose Nascimento Sobrinho and Nelson Hamerschlak and Luciana Corr{\^e}a},
  journal={Hematological oncology},
  year={2015},
  volume={33 3},
  pages={152-8}
}
Melphalan followed by hematopoietic stem-cell transplantation (HSCT) is the standard treatment for multiple myeloma and other hematopoietic neoplasms. However, high doses of melphalan cause severe oral mucositis (OM). The objective was to verify the efficacy of cryotherapy plus laser therapy on reduction of OM severity. HSCT patients undergoing melphalan chemotherapy (n = 71) were randomly divided into two groups according to OM treatment: oral cryotherapy performed with ice chips for 1 h 35… CONTINUE READING
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