Efficacy of commercial and field-strain Mycobacterium paratuberculosis vaccinations with recombinant IL-12 in a bovine experimental infection model.

@article{Uzonna2003EfficacyOC,
  title={Efficacy of commercial and field-strain Mycobacterium paratuberculosis vaccinations with recombinant IL-12 in a bovine experimental infection model.},
  author={Jude Eze Uzonna and Paula Chilton and Robert H. Whitlock and Perry L. Habecker and Phillip Scott and Raymond W. Sweeney},
  journal={Vaccine},
  year={2003},
  volume={21 23},
  pages={3101-9}
}
The efficacy of commercial (Strain 18) and field-isolate paratuberculosis vaccine preparations was investigated. The effect of prior exposure to Mycobacterium paratuberculosis and the adjuvant effect of rIL-12 on vaccine efficacy were also tested. Both Strain 18 and field-isolate vaccines induced strong local, systemic and enteric IFN-gamma responses. A significant reduction in mycobacterial colonization was observed when calves were vaccinated with the field-isolate prior to challenge, but not… CONTINUE READING

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