Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model.

@article{Mi2009EfficacyOC,
  title={Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model.},
  author={Ruifang Mi and Jianhui Ma and Dechang Zhang and Limin Li and Hongbing Zhang},
  journal={Journal of genetics and genomics = Yi chuan xue bao},
  year={2009},
  volume={36 6},
  pages={
          355-61
        }
}
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome which afflicts multiple organs and for which there is no cure, such that TSC patients may develop severe mental retardation and succumb to renal or respiratory failure. TSC derives from inactivating mutations of either the TSC1 or TSC2 tumor suppressor gene, and the resulting inactivation of the TSC1/TSC2 protein complex causes hyperactivation of the mammalian target of rapamycin (mTOR), leading to uncontrolled cell growth… CONTINUE READING
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