Efficacy of colistin/rifampin combination in experimental rat models of sepsis due to a multiresistant Pseudomonas aeruginosa strain.

@article{Cirioni2007EfficacyOC,
  title={Efficacy of colistin/rifampin combination in experimental rat models of sepsis due to a multiresistant Pseudomonas aeruginosa strain.},
  author={Oscar Cirioni and Roberto Ghiselli and Fiorenza Orlando and C. A. Di Silvestri and Federico Mocchegiani and Marco Bruno Lucio Rocchi and Leonardo Chiodi and Alessandra Abbruzzetti and Vittorio Saba and Giorgio Scalise and Andrea Giacometti},
  journal={Critical care medicine},
  year={2007},
  volume={35 7},
  pages={1717-23}
}
OBJECTIVE To investigate the efficacy of rifampin and colistin in three experimental rat models of Pseudomonas aeruginosa sepsis. DESIGN Prospective, randomized, controlled animal study. SETTING Research laboratory in a university hospital. SUBJECTS Adult male Wistar rats. INTERVENTIONS Adult male Wistar rats were given a) an intraperitoneal injection of 1 mg of P. aeruginosa 10 lipopolysaccharide; b) 2 x 10(10) colony-forming units of P. aeruginosa ATCC 27853; and c) 2 x 10(10) colony… CONTINUE READING