Efficacy of cannabidiol in subjects with refractory epilepsy relative to concomitant use of clobazam

@article{Savage2020EfficacyOC,
  title={Efficacy of cannabidiol in subjects with refractory epilepsy relative to concomitant use of clobazam},
  author={Taylor E. Savage and Jo Sourbron and Patricia L. Bruno and Lauren A. Skirvin and Emma Wolper and Christina J. Anagnos and Elizabeth A Thiele},
  journal={Epilepsy Research},
  year={2020},
  volume={160}
}

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References

SHOWING 1-10 OF 23 REFERENCES

Efficacy and Safety of Cannabidiol in Epilepsy: A Systematic Review and Meta-Analysis

The aim of the study was to estimate the efficacy and safety of CBD as adjunctive treatment in patients with epilepsy using meta-analytical techniques.

Cannabidiol in patients with treatment-resistant epilepsy

Purified Cannabidiol for Treatment of Refractory Epilepsies in Pediatric Patients with Developmental and Epileptic Encephalopathy

Efficacy, safety and tolerability of CBD treatment were assessed through the evaluation of seizure frequency and reports of adverse effects, and data suggest that CBD may have beneficial effects in patients with DEE and an acceptable safety profile.

Efficacy and Safety of Adjunctive Cannabidiol in Patients with Lennox–Gastaut Syndrome: A Systematic Review and Meta-Analysis

Adjunctive CBD resulted in a greater reduction in seizure frequency and a higher rate of AEs than placebo in patients with LGS presenting seizures uncontrolled by concomitant AEDs.

Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome

This study provides Class I evidence that for children with Dravet syndrome, CBD resulted in more AEs than placebo but was generally well-tolerated.