Efficacy of camptothecin and polymer-conjugated camptothecin in tumor spheroids and solid tumors

@article{Ying2007EfficacyOC,
  title={Efficacy of camptothecin and polymer-conjugated camptothecin in tumor spheroids and solid tumors},
  author={Victoria Ying and K. Haverstick and R. Page and W. Saltzman},
  journal={Journal of Biomaterials Science, Polymer Edition},
  year={2007},
  volume={18},
  pages={1283 - 1299}
}
Camptothecin (CPT) is an anti-cancer drug with low solubility in aqueous solutions, which limits its efficacy during chemotherapy. To bypass this problem, CPT was conjugated to poly(ethylene glycol) (PEG) to make CPT more hydrophilic: CM-PEG-CPT (carboxylmethylpoly(ethlyene glycol)-camptothecin), CM-PEG-GLY-CPT (carboxylmethyl-poly(ethlyene glycol)-glycine-camptothecin) and CM-PEG-SAR-CPT (carboxylmethyl-poly(ethlyene glycol)-sarcosine camptothecin) were synthesized. These conjugates differed… Expand
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