Efficacy of butyrate in the treatment of diarrhoea-predominant irritable bowel syndrome

  title={Efficacy of butyrate in the treatment of diarrhoea-predominant irritable bowel syndrome},
  author={Emidio Scarpellini and Ernesto Cristiano Lauritano and Andrea Lupascu and Carlo Petruzzellis and Marialuisa Novi and Davide Roccarina and Maurizio Gabrielli and Michele Serricchio and Giovanni Battista Gasbarrini and Antonio Gasbarrini},
  journal={Digestive and Liver Disease Supplements},
Abstract Introduction Short-chain fatty acids affect enterocyte metabolism and differentiation. Butyric acid in particular is already used in ulcerative rectal colitis, pouchitis and antibiotic-induced diarrhoea. Aims To assess the efficacy of butyrate in the treatment of irritable bowel syndrome (IBS). Patients Fifty patients with IBS were treated using enteric-coated sodium butyrate tablets at a dosage of 1 g/day for 30 days. Methods The patients were divided into two subgroups: constipation… Expand
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