Efficacy of bronchodilator therapy in bronchiolitis. A meta-analysis.

@article{Kellner1996EfficacyOB,
  title={Efficacy of bronchodilator therapy in bronchiolitis. A meta-analysis.},
  author={James Duncan Kellner and Arne Ohlsson and Anne Gadomski and Elaine E. L. Wang},
  journal={Archives of pediatrics \& adolescent medicine},
  year={1996},
  volume={150 11},
  pages={
          1166-72
        }
}
OBJECTIVE To determine if bronchodilators are efficacious in treating bronchiolitis. DATA SOURCES A search of bibliographic databases (MEDLINE, Excerpta Medica, and Reference Update) for bronchiolitis and albuterol or ipratropium bromide, or adrenergic agents or bronchodilator agents. Reference lists were also used. STUDY SELECTION Randomized, placebo-controlled trials of bronchodilator treatment in bronchiolitis were selected by 2 investigators. Fifteen of 89 identified publications met… Expand
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Epinephrine for bronchiolitis.
TLDR
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Efficacy of oral dexamethasone in outpatients with acute bronchiolitis.
TLDR
Outpatients with moderate-to-severe acute bronchiolitis derive significant clinical and hospitalization benefit from oral dexamethasone treatment in the initial 4 hours of therapy. Expand
A randomized, controlled trial of nasal phenylephrine in infants hospitalized for bronchiolitis.
TLDR
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Oral salbutamol for symptomatic relief in mild bronchiolitis a double blind randomized placebo controlled trial.
TLDR
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TLDR
Albuterol is as effective as oral placebo in the management of bronchiolitis and change in the state of the infant during the trial had significant effects on respiratory rate and clinical score. Expand
Bronchodilators for treatment of mild bronchiolitis: a factorial randomised trial.
TLDR
Inhaled bronchodilators did not improve the condition of hospitalised mild bronchiolitis and the change in oxygen saturation of recipients of both agents was significantly better than that of recipient of salbutamol alone or ipratropium bromide alone. Expand
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TLDR
It is concluded that salbutamol is safe and effective for the initial treatment of young children with acute bronchiolitis. Expand
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TLDR
Although there appears to be an age-dependent degree of response, metaproterenol is effective in relieving the respiratory distress of young acutely wheezing children, including those with documented respiratory syncytial virus bronchiolitis. Expand
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TLDR
Nebulized albuterol significantly improved the clinical score and reduced the respiratory rate of those with recurrent wheezing relative to those in the randomized groups, and there was no demonstrable efficacy of orally administered or nebulized al buterol in relieving the respiratory distress of infants with bronchiolitis in Egypt. Expand
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TLDR
It is concluded that nebulized albuterol constitutes a safe and effective treatment of infants with bronchiolitis. Expand
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To test the efficacy of a combined alpha- and beta-receptor agonist in acute bronchiolitis, we compared inhaled racemic epinephrine with salbutamol in a double-blind, crossover, randomized protocol.Expand
Efficacy of adding nebulized ipratropium bromide to nebulized albuterol therapy in acute bronchiolitis.
TLDR
The addition of ipratropium resulted in no additional benefit with respect to decrease in the respiratory rate, and the number of "nonresponders" and "clear responders" was also very similar in both groups. Expand
Corticosteroids do not affect the clinical or physiological status of infants with bronchiolitis
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It is concluded that corticosteroids do not change the rate of clinical improvement in acute bronchiolitis, nor do they effect lung function 2–4 weeks later. Expand
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TLDR
This study demonstrates that treatment with nebulised racemic adrenaline improved oxygenation and clinical signs in hospitalised children aged less than 18 months with bronchiolitis. Expand
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