Efficacy of bronchodilator therapy in bronchiolitis. A meta-analysis.

@article{Kellner1996EfficacyOB,
  title={Efficacy of bronchodilator therapy in bronchiolitis. A meta-analysis.},
  author={James D Kellner and Arne Ohlsson and Anne Gadomski and Elaine E. L. Wang},
  journal={Archives of pediatrics \& adolescent medicine},
  year={1996},
  volume={150 11},
  pages={
          1166-72
        }
}
OBJECTIVE To determine if bronchodilators are efficacious in treating bronchiolitis. DATA SOURCES A search of bibliographic databases (MEDLINE, Excerpta Medica, and Reference Update) for bronchiolitis and albuterol or ipratropium bromide, or adrenergic agents or bronchodilator agents. Reference lists were also used. STUDY SELECTION Randomized, placebo-controlled trials of bronchodilator treatment in bronchiolitis were selected by 2 investigators. Fifteen of 89 identified publications met… 

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References

SHOWING 1-10 OF 37 REFERENCES

Efficacy of albuterol in the management of bronchiolitis.

Albuterol is as effective as oral placebo in the management of bronchiolitis and change in the state of the infant during the trial had significant effects on respiratory rate and clinical score.

Bronchodilators for treatment of mild bronchiolitis: a factorial randomised trial.

Inhaled bronchodilators did not improve the condition of hospitalised mild bronchiolitis and the change in oxygen saturation of recipients of both agents was significantly better than that of recipient of salbutamol alone or ipratropium bromide alone.

The efficacy of nebulized metaproterenol in wheezing infants and young children.

Although there appears to be an age-dependent degree of response, metaproterenol is effective in relieving the respiratory distress of young acutely wheezing children, including those with documented respiratory syncytial virus bronchiolitis.

Nebulized albuterol in acute bronchiolitis.

Efficacy of adding nebulized ipratropium bromide to nebulized albuterol therapy in acute bronchiolitis.

The addition of ipratropium resulted in no additional benefit with respect to decrease in the respiratory rate, and the number of "nonresponders" and "clear responders" was also very similar in both groups.

Corticosteroids do not affect the clinical or physiological status of infants with bronchiolitis

It is concluded that corticosteroids do not change the rate of clinical improvement in acute bronchiolitis, nor do they effect lung function 2–4 weeks later.

Nebulised racemic adrenaline in the treatment of acute bronchiolitis in infants and toddlers.

This study demonstrates that treatment with nebulised racemic adrenaline improved oxygenation and clinical signs in hospitalised children aged less than 18 months with bronchiolitis.