Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication

@article{Shih2000EfficacyOB,
  title={Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication},
  author={T. Shih and J. Mcdonough},
  journal={Archives of Toxicology},
  year={2000},
  volume={74},
  pages={165-172}
}
  • T. Shih, J. Mcdonough
  • Published 2000
  • Chemistry, Medicine
  • Archives of Toxicology
  • Abstract The ability of the nerve agents tabun, sarin, soman, GF, VR, and VX to produce brain seizures and the effectiveness of the anticholinergics biperiden HCl or atropine SO4 as an anticonvulsant treatment were studied in a guinea-pig model. All animals were implanted a week prior to the experiment with cortical electrodes for electroencephalogram (EEG) recordings. On the day of exposure, the animals were pretreated with pyridostigmine (0.026 mg/kg, i.m.) 30 min prior to challenge with a 2… CONTINUE READING
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    References

    SHOWING 1-10 OF 61 REFERENCES
    Atropine and/or diazepam therapy protects against soman-induced neural and cardiac pathology.
    • 137
    Anticonvulsant effects of diazepam and MK-801 in soman poisoning
    • T. Shih
    • Chemistry, Medicine
    • Epilepsy Research
    • 1990
    • 80
    Evaluation of Anticonvulsant Drugs for Soman-Induced Seizure Activity
    • 24
    Anticonvulsant Actions of Anticholinergic Drugs in Soman Poisoning
    • 87
    Efficacy of diazepam and avizafone against soman-induced neuropathology in brain of rats.
    • 56
    Pharmacological modulation of soman-induced seizures
    • 206
    Effect of diazepam upon soman-induced seizure activity and convulsions.
    • J. Lipp
    • Psychology, Medicine
    • Electroencephalography and clinical neurophysiology
    • 1972
    • 98
    Relationship between reversible acetylcholinesterase inhibition and efficacy against soman lethality.
    • 121
    • Highly Influential
    Sarin-induced neuropathology in rats
    • 107
    • Highly Influential