Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication

@article{Shih2000EfficacyOB,
  title={Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication},
  author={T.-M. Shih and John H. McDonough},
  journal={Archives of Toxicology},
  year={2000},
  volume={74},
  pages={165-172}
}
The ability of the nerve agents tabun, sarin, soman, GF, VR, and VX to produce brain seizures and the effectiveness of the anticholinergics biperiden HCl or atropine SO4 as an anticonvulsant treatment were studied in a guinea-pig model. All animals were implanted a week prior to the experiment with cortical electrodes for electroencephalogram (EEG) recordings. On the day of exposure, the animals were pretreated with pyridostigmine (0.026 mg/kg, i.m.) 30 min prior to challenge with a 2 × LD50… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 58 references

Review of nerve agent inhibitors and reactivators of acctylcholincstcrase

DH Moore, CB Clifford, IT Crawford, GM Cole, JM Baggett
1995
View 4 Excerpts
Highly Influenced

Anticholinestcrase agents

P Taylor
1985
View 3 Excerpts
Highly Influenced

Characterization and treatment of the toxicity of 0isobutyl S( 2( diethylamino ) ethyl ) methylphosphonothioate , a structural isomer of VX , in guinea pigs

JH McDonough, Shih T-M
J Am Coll Toxicol • 1997

Characterization and treatment of the toxicity of ft - isobutyl 5 - ( 2 - ( diethylami - no ) ethyl ) mcthylphosphonothioatc . a structural isomer of VX , in guinea pigs

DM Maxwell, KM Brecht, I Koplovitz
J Am Coll Toxicol • 1997
View 1 Excerpt

Ncuropharmacological mechanisms of nerve agent - induced seizures and neuropathology

JH McDonough, Shih T-M
Ncurosci Biobchav Rev • 1997

Neuropharmacological mechanisms of nerve agentinduced seizures and neuropathology

JH McDonough, NK Jaax, RA Crowley, MZ Mays, HE Modrow
Neurosci Biobehav Rev • 1997

Evaluation of anticonvulsant drues for soman - induced seizure activity

Shih T-M, I Koplovitz, JH McDonough
J Am Coll Toxicol • 1996

Pharmacological antagonism

Shih T-M, JH McDonough
1996

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