Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats.

@article{Stracke2001EfficacyOB,
  title={Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats.},
  author={Hilmar H G Stracke and Hans Peter Hammes and D Werkmann and Konstantinos J. Mavrakis and Irmgard Bitsch and Michael Netzel and Jennifer Geyer and Wolfgang Koepcke and Cristina Maria Sauerland and Reinhard Georg Bretzel and Konrad F. Federlin},
  journal={Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  year={2001},
  volume={109 6},
  pages={330-6}
}
In rats with streptozotocin (STZ) induced diabetes the effect of (watersoluble) thiamine nitrate and of (lipidsoluble) benfotiamine on peripheral nerve function (motor nerve conduction velocity) as well as on the formation of advanced glycation end-products in peripheral nerve tissue was studied. In one group of animals drug administration was started immediately after diabetes induction (prevention study) and in another group two months after diabetes induction (treatment study). Motor nerve… CONTINUE READING

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