• Corpus ID: 51900978

Efficacy of autologous adipose tissue-derived stem cells with extracellular matrix and hyaluronic acid on human hip osteoarthritis

@article{Pak2017EfficacyOA,
  title={Efficacy of autologous adipose tissue-derived stem cells with extracellular matrix and hyaluronic acid on human hip osteoarthritis},
  author={Jaewoo Pak and Jung Hun Lee and Kwang Seung Park and Sang Hee Lee},
  journal={Biomedical Research-tokyo},
  year={2017},
  volume={28},
  pages={1654-1658}
}
The aim of this study is to demonstrate that percutaneous injections of autologous Adipose Tissue- Derived Stem Cells (ASCs) and Extracellular Matrix (ECM) in the form of adipose Stromal Vascular Fraction (SVF), along with Hyaluronic Acid (HA) and Platelet-Rich Plasma (PRP) activated by calcium chloride could regenerate cartilage-like tissue in human hip Osteoarthritis (OA) patient. Autologous lipoaspirates were obtained from adipose tissue of the abdominal origin. Afterwards, the lipoaspirates… 

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References

SHOWING 1-10 OF 17 REFERENCES

Cartilage Regeneration in Human with Adipose Tissue-Derived Stem Cells: Current Status in Clinical Implications

A systematic review of currently available clinical studies involving ADSCs in the form of SVF and in the culture-expanded form, with or without PRP, highlighting the clinical effectiveness and safety in treating OA.

Autologous injectable tissue-engineered cartilage by using platelet-rich plasma: experimental study in a rabbit model.

  • Wei WuFulin ChenYanpu LiuQ. MaT. Mao
  • Medicine, Biology
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • 2007

Multilineage cells from human adipose tissue: implications for cell-based therapies.

The data support the hypothesis that a human lipoaspirate contains multipotent cells and may represent an alternative stem cell source to bone marrow-derived MSCs.

Human adipose tissue is a source of multipotent stem cells.

To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches and PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.

Extracellular matrix scaffolds for cartilage and bone regeneration.

THE BIOLOGICAL EFFECT OF PLATELET RICH-PLASMA ON THE FRACTURE HEALING PROCESS.

It is demonstrated that PRP initiates proliferation in hMSCs and osteoblasts, enhances BMP-2 mRNA expression and induces osteoblast differentiation and maturation in human MSC cultures, and highlights the potential for Caption™ derived PRP to enhance bone repair.

Comparative analysis of highly defined proteases for the isolation of adipose tissue-derived stem cells.

The results demonstrate that the highly purified proteases provide a valuable alternative to crude collagenase preparations, especially in scenarios where a high definition and reproducibility of the digestion process is of importance.

Molecular and morphometric description of adipose tissue during weight changes: a quantitative tool for assessment of tissue texture.

The aim of this study was to evaluate the morphometric changes of adipose tissue of lean and obese rats as assessed by computerized image analysis (IA) system in experimental conditions, with different degrees of adiposity to validate measures obtained by image analysis and correlate these changes to expression of genes involved in lipid deposition and mobilization in adiposes tissue.

Psychometric properties of the functional rating index in patients with low back pain

The FRI is less reliable than the Oswestry but appears to have comparable validity and responsiveness, and before the FRI can be recommended for widespread use in patients with neck and low back pain, it should be further tested in patientsWith neck pain.