Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: an open-label randomised controlled trial.

@article{Obonyo2010EfficacyOA,
  title={Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: an open-label randomised controlled trial.},
  author={Charles O Obonyo and Erick M. O. Muok and Pauline N. M. Mwinzi},
  journal={The Lancet. Infectious diseases},
  year={2010},
  volume={10 9},
  pages={603-11}
}
BACKGROUND Schistosomiasis is an important parasitic disease in Kenya. Decreasing susceptibility of schistosomes to praziquantel, the major drug used to reduce disease morbidity, has made assessment of new antischistosomal drugs a priority. We aimed to assess the safety and efficacy of an artesunate-based combination drug in the treatment of schistosomiasis. METHODS In this open-label randomised trial in Rarieda district of western Kenya, we enrolled school children (aged 6-15 years) who had… CONTINUE READING
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