Efficacy of annual colonoscopic surveillance in individuals with hereditary nonpolyposis colorectal cancer.

@article{Engel2010EfficacyOA,
  title={Efficacy of annual colonoscopic surveillance in individuals with hereditary nonpolyposis colorectal cancer.},
  author={Christoph Engel and Nils Rahner and Karsten Schulmann and Elke Holinski-Feder and Timm O. Goecke and Hans Konrad Schackert and Matthias Kloor and Verena Steinke and Holger Vogelsang and Gabriela Moeslein and Heike Goergens and Stefan Dechant and Magnus von Knebel Doeberitz and Josef Rueschoff and Nicolaus Friedrichs and Reinhard Buettner and Markus L{\"o}ffler and P. Propping and Wolff -H. Schmiegel},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2010},
  volume={8 2},
  pages={174-82}
}
BACKGROUND & AIMS Individuals with hereditary nonpolyposis colorectal cancer (HNPCC; Lynch syndrome) have a high risk for developing colorectal cancer (CRC). We evaluated the efficacy of annual surveillance colonoscopies to detect adenomas and CRCs. METHODS In a prospective, multicenter cohort study, 1126 individuals underwent 3474 colonoscopies. We considered individuals from 3 groups of HNPCC families: those with a pathogenic germline mutation in a mismatch repair gene (MUT group), those… CONTINUE READING

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