Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: A meta-analysis

@article{Na2014EfficacyOA,
  title={Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: A meta-analysis},
  author={Kyoung-Sae Na and Kang Joon Lee and Ji Sung Lee and Young Sung Cho and Han-Yong Changwon Jung},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2014},
  volume={48},
  pages={79-85}
}
BACKGROUND Numerous studies have reported that inflammation is closely associated with depression, and adjunctive non-steroidal anti-inflammatory drug (NSAID) treatment has been suggested as a novel therapeutic approach for depression. METHODS We searched electronic databases including Medline, Embase, and the Cochrane Central Register of Controlled Trials. We only included randomized controlled trials comparing adjunctive NSAIDs with placebos for treating depressive episodes. RESULTS Of… Expand
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TLDR
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This study indicates celecoxib as a potential monotherapy treatment strategy for mild to moderate depression in patients with colorectal cancer who underwent chemotherapy with significant improvement in scores of the Hamilton Depression rating Scale. Expand
Effect of Anti-inflammatory Treatment on Depression , Depressive Symptoms , and Adverse Effects A Systematic Review andMeta-analysis of Randomized Clinical Trials
RESULTS Ten publications reporting on 14 trials (6262 participants) were included: 10 trials evaluated the use of nonsteroidal anti-inflammatory drugs (NSAIDs) (n = 4258) and 4 investigated cytokineExpand
Anti-inflammatory treatment of depression: study protocol for a randomised controlled trial of vortioxetine augmented with celecoxib or placebo
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Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trials.
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The analysis suggests that anti-inflammatory treatment, in particular celecoxib, decreases depressive symptoms without increased risks of adverse effects, and supports a proof-of-concept concerning the use of anti- inflammatory treatment in depression. Expand
Effect of Anti-inflammatory Treatment on Depression , Depressive Symptoms , and Adverse Effects
RESULTS Ten publications reporting on 14 trials (6262 participants) were included: 10 trials evaluated the use of nonsteroidal anti-inflammatory drugs (NSAIDs) (n = 4258) and 4 investigated cytokineExpand
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Modulation of the inflammatory response through targeted inhibition of the enzyme COX-2 by means of CBX reduces TRBDD and augments and accelerates treatment response in an efficacious and safe manner. Expand
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Celecoxib seems to possess superior antidepressive effects compared with diclofenac in breast cancer patients with mild to moderate depression. Expand
Efficacy of Sertraline Plus Placebo or Add-On Celecoxib in Major Depressive Disorder: Macrophage Migration Inhibitory Factor as a Promising Biomarker for Remission After Sertraline—Results From a Randomized Controlled Clinical Trial
Introduction: Previous research delivers strong indications that inflammatory activation leads to treatment resistance in a subgroup of patients with Major Depressive Disorder (MDD). Thus, tailoredExpand
Are Non-steroidal Anti-Inflammatory Drugs Clinically Suitable for the Treatment of Symptoms in Depression-Associated Inflammation?
  • B. Baune
  • Medicine
  • Current topics in behavioral neurosciences
  • 2017
TLDR
Although meta-analyses appear to support the use of NSAIDs in acute depression, the overall effect is mainly biased by the effects of celecoxib for which the best evidence exists to date, and the possible impact of anti-inflammatory treatments on immune changes in different phases of depression warrants caution. Expand
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