Efficacy of activated charcoal hemoperfusion in removing lethal doses of barbiturates and salicylate from the blood of rats and dogs.

@article{Hill1976EfficacyOA,
  title={Efficacy of activated charcoal hemoperfusion in removing lethal doses of barbiturates and salicylate from the blood of rats and dogs.},
  author={Julian B. Hill and F L Palaia and J L McAdams and Philip J. Palmer and St{\'e}phanie Maret},
  journal={Clinical chemistry},
  year={1976},
  volume={22 6},
  pages={754-60}
}
Rats were injected intraperitoneally with lethal doses of sodium pentobarbital (115 mg/kg) or a lethal mixture of sodium salicylate (500 mg/kg) and sodium acetazolamide (25 mg/kg). Within about 20 min, part of each group was connected to an extracorporeal circuit containing uncoated activated charcoal and part to an empty control circuit. After a 90-min… CONTINUE READING