Efficacy of a genetically engineered Candida albicans tet-NRG1 strain as an experimental live attenuated vaccine against hematogenously disseminated candidiasis.

@article{Saville2009EfficacyOA,
  title={Efficacy of a genetically engineered Candida albicans tet-NRG1 strain as an experimental live attenuated vaccine against hematogenously disseminated candidiasis.},
  author={Stephen P. Saville and Anna L. Lazzell and Ashok Kumar Chaturvedi and Carlos Hern{\'a}ndez – Monteagudo and Jos{\'e} Luis L{\'o}pez-Ribot},
  journal={Clinical and vaccine immunology : CVI},
  year={2009},
  volume={16 3},
  pages={430-2}
}
We report on the efficacy of the genetically engineered Candida albicans tet-NRG1 strain as an experimental live, attenuated vaccine against disseminated candidiasis in both immunocompetent and immunodeficient mice mostly dependent on T-cell immunity. This experimental vaccination model may represent an important tool to unravel the mechanisms of protective immunity during candidiasis.