Efficacy of Zinc Against Common Cold Viruses: An Overview

@article{Hulisz2004EfficacyOZ,
  title={Efficacy of Zinc Against Common Cold Viruses: An Overview},
  author={Darrell T. Hulisz},
  journal={Journal of the American Pharmacists Association},
  year={2004},
  volume={44},
  pages={594 - 603}
}
  • D. Hulisz
  • Published 1 September 2004
  • Medicine
  • Journal of the American Pharmacists Association
ABSTRACT Objective To review the laboratory and clinical evidence of the medicinal value of zinc for the treatment of the common cold. Data Sources Published articles identified through Medline (1980–2003) using the search terms zinc, rhinovirus, and other pertinent subject headings. Additional sources were identified from the bibliographies of the retrieved… 
WITHDRAWN: Zinc for the common cold.
TLDR
Zinc administered within 24 hours of onset of symptoms reduces the duration of common cold symptoms in healthy people but some caution is needed due to the heterogeneity of the data.
Treatment of naturally acquired common colds with zinc: a structured review.
  • T. Caruso, C. Prober, J. Gwaltney
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2007
TLDR
This structured review suggests that the therapeutic effectiveness of zinc lozenges has yet to be established, and one well-designed study did report a positive effect of zinc nasal gel.
Cochrane Review: Zinc for the common cold
TLDR
Zinc administered within 24 hours of onset of symptoms reduces the duration and severity of the common cold in healthy people and when supplemented for at least five months, it reduces cold incidence, school absenteeism and prescription of antibiotics in children.
Zinc for the common cold.
TLDR
Zinc administered within 24 hours of onset of symptoms reduces the duration of common cold symptoms in healthy people but some caution is needed due to the heterogeneity of the data.
Is intranasal zinc effective and safe for the common cold? A systematic review and meta-analysis.
TLDR
Results from individual trials suggest some benefit from zinc for symptoms of a common cold, at least in adults, and pooling the results for symptom relief at day 3, in a conservative meta-analysis suggests a non-significant benefit.
Antiviral activity of plants and their isolated bioactive compounds: An update
TLDR
The aim of this work is to summarize the updated evidence for antiviral activity of different plants and their isolated bioactive compounds, evaluating also the potential interactions, which can occur in cotreatment with conventional antiviral drugs.
The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis
TLDR
The potential of zinc as preventive and therapeutic agent alone or in combination with other strategies, as zinc meets all the above described criteria is discussed.
Zinc for the prevention and treatment of SARS-CoV-2 and other acute viral respiratory infections: a rapid review
Background The global COVID-19 pandemic has prompted an urgent search for interventions to prevent and treat SARS-CoV-2. Higher risk of infection and adverse outcomes coincide with populations with
Rapid review protocol: Zinc for the prevention or treatment of COVID-19 and other coronavirus-related respiratory tract infections
Abstract Background . The global COVID-19 pandemic has
Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases
TLDR
This review aims to summarize the respective findings and to discuss possible molecular mechanisms by which zinc could influence viral, bacterial, and parasitic infections, autoimmune diseases, and the response to vaccination.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Zinc Gluconate Lozenges for Treating the Common Cold
TLDR
This was a pragmatic study designed to determine the efficacy of zinc gluconate lozenges in reducing clinical symptom scores under conditions that reflected usual medical care for the common cold.
Duration of Symptoms and Plasma Cytokine Levels in Patients with the Common Cold Treated with Zinc Acetate
TLDR
The duration ofcold symptoms in zinc-treated and placebo-treated participants was determined and plasma zinc and proinflammatory cytokine levels were assayed on the day 1 of the study and at the end of the resolution of cold symptoms in both groups.
How does zinc modify the common cold? Clinical observations and implications regarding mechanisms of action.
TLDR
It is proposed that transient elevation of Zn2+ concentration in and around the nasal cavity facilitates Zn 2+ complexation with known intercellular adhesion molecule binding sites on rhinovirus surfaces which prevents rhinvirus binding to cells and interrupts infection.
A meta-analysis of zinc salts lozenges and the common cold.
TLDR
The evidence for effectiveness of zinc salts lozenges in reducing the duration of common colds is still lacking and a meta-analysis of published randomized clinical trials using a random effects model was conducted.
Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges
TLDR
It is concluded that zinc gluconate lozenges are reasonably well tolerated and that they have a significant effect on the signs and symptoms of colds caused by rhinoviruses, although the mechanism of action remains obscure.
Elimination of efficacy by additives in zinc acetate lozenges for common colds.
  • G. Eby
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2001
TLDR
The cumulative effect of the above omissions teaches readers that zinc acetate lozenges in general do not have efficacy against common cold; however, properly made zinc acetates work very well in reducing the duration of common colds.
Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds.
  • R. Turner
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2001
TLDR
Zinc treatment had no effect on total symptom score, rhinorrhea, nasal obstruction, or the proportion of infected volunteers who developed clinical colds, and data do not support a role for intranasal zinc gluconate for prevention or treatment of the common cold.
Zinc-induced suppression of inflammation in the respiratory tract, caused by infection with human rhinovirus and other irritants.
TLDR
Zn2+ complexes with proteins of critical nerve endings and surface proteins of human rhinovirus (HRV) block docking of HRV on intercellular adhesion molecule-1 (ICAM-1) on somatic cells, thereby interrupting HRV infection.
Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults.
  • S. Mossad
  • Medicine
    QJM : monthly journal of the Association of Physicians
  • 2003
TLDR
Zincum gluconicum nasal gel shortens duration and reduces symptom severity of the common cold in healthy adults, when started within 24-48 h of the onset of illness.
Zinc Gluconate Lozenges for Treating the Common Cold
TLDR
Until further investigations demonstrate the long-term safety of therapy with zinc gluconate, it is imprudent for persons known to be hemochromatosis homozygotes or heterozygotes to use zinc salts to treat colds.
...
1
2
3
4
...