Efficacy of Wolbachia-infected mosquito deployments for the control of dengue

  title={Efficacy of Wolbachia-infected mosquito deployments for the control of dengue},
  author={Adi Utarini and Citra Indriani and Riris Andono Ahmad and Warsito Tantowijoyo and Eggi Arguni and Muhammad Ridwan Ansari and Endah Supriyati and Dwi Satria Wardana and Yeti Meitika and Inggrid Ernesia and Indah Nurhayati and Equatori Prabowo and Bekti Andari and Benjamin R. Green and Lauren Hodgson and Zoe Cutcher and Edwige Rancès and Peter A. Ryan and Scott L. O'Neill and Suzanne M. Dufault and Stephanie K. Tanamas and Nicholas P Jewell and Katherine L. Anders and Cameron P. Simmons},
  journal={The New England Journal of Medicine},
  pages={2177 - 2186}
Background: Aedes aegypti mosquitoes infected with Wolbachia pipientis (wMel strain) have reduced potential to transmit dengue viruses. Methods: We conducted a cluster randomised trial of deployments of wMel-infected Ae. aegypti for control of dengue in Yogyakarta City, Indonesia. Twenty-four geographic clusters were randomly allocated to receive wMel deployments as an adjunct to local mosquito control measures; or to continue with local mosquito control measures only. A test-negative design… 

Effectiveness of Wolbachia-infected mosquito deployments in reducing the incidence of dengue and chikungunya in Niteroi, Brazil: a quasi-experimental study

It is demonstrated that wMel Wolbachia can be successfully introgressed into Ae.

Effectiveness of Wolbachia-infected mosquito deployments in reducing the incidence of dengue and other Aedes-borne diseases in Niterói, Brazil: A quasi-experimental study

It is demonstrated that wMel Wolbachia can be successfully introgressed into Ae.

EVITA Dengue: a cluster-randomized controlled trial to EValuate the efficacy of Wolbachia-InfecTed Aedes aegypti mosquitoes in reducing the incidence of Arboviral infection in Brazil

The EVITA Dengue trial design (DMID 17-0111), which assesses the efficacy in decreasing arbovirus transmission of an innovative approach developed by the World Mosquito Program for vector modification of Aedes mosquitoes by Wolbachia pipientis, represents a critical step towards robustness and rigor for how vector control methods are assessed.

The impact of city-wide deployment of Wolbachia-carrying mosquitoes on arboviral disease incidence in Medellín and Bello, Colombia: study protocol for an interrupted time-series analysis and a test-negative design study

The study findings will add to an accumulating body of evidence from global field sites on the efficacy of the Wolbachia method in reducing arboviral disease incidence, and can inform decisions on wider public health implementation of this intervention in the Americas and beyond.

Wolbachia wAlbB inhibit dengue and Zika infection in the mosquito Aedes aegypti with an Australian background

It is demonstrated that the Wolbachia wAlbB2-F4 strain, in addition to being suitable for suppression programs, can be effective in population replacement programs given its high inhibition of virus infection in mosquitoes.

Disruption of spatiotemporal dependence in dengue transmission by wMel Wolbachia in Yogyakarta, Indonesia

There is compelling evidence that introgression of wMel Wolbachia into Aedes aegypti mosquito populations interrupts focal dengue virus transmission, leading to reduced case incidence.

Disruption of spatiotemporal clustering in dengue cases by wMel Wolbachia in Yogyakarta, Indonesia

Introgression of wMel Wolbachia into Aedes aegypti mosquito populations interrupts focal dengue virus transmission leading to reduced case incidence; the true intervention effect may be greater than the 77% efficacy measured in the primary analysis of the Yogyakarta trial.

Dengue virus population genetics in Yogyakarta, Indonesia prior to city-wide Wolbachia deployment.

  • E. ArguniC. Indriani R. T. Sasmono
  • Medicine
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2022

High Temperature Cycles Result in Maternal Transmission and Dengue Infection Differences Between Wolbachia Strains in Aedes aegypti

Compared the effects of a temperature cycle mimicking natural breeding sites in tropical climates on two Wolbachia strains, currently used for open field trials, which underline the significance of understanding the impact of environmental factors on released mosquitoes, in order to ensure the most efficient strategy for dengue control.

Efficacy of a spatial repellent for control of Aedes-borne virus transmission: A cluster-randomized trial in Iquitos, Peru

This trial provides the first conclusive evidence of significant protective efficacy by any chemical vector control intervention, in this case a spatial repellent, to reduce the risk of Aedes aegypti transmission.



Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis

A significant reduction in dengue incidence is demonstrated following successful introgression of Wolbachia into local Ae.

Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes

Significance In laboratory experiments, Wolbachia (wMel strain)-infected Aedes aegypti are refractory to disseminated arboviral infections. Yet previous characterizations of wMel-mediated blocking

Quantitative real-time PCR detection of Zika virus and evaluation with field-caught Mosquitoes

This assay is a useful tool for detection of ZIKV infection in regions where a number of other clinically indistinguishable arboviruses like dengue or chikungunya co-circulate.

Assessing quality of life-shortening Wolbachia-infected Aedes aegypti mosquitoes in the field based on capture rates and morphometric assessments

The lower fitness of w MelPop-CLA infection under field conditions is confirmed, helping to explain challenges associated with a successful invasion by this strain of Wolbachia.

The Relative Importance of Innate Immune Priming in Wolbachia-Mediated Dengue Interference

The results reinforce the idea that the fundamental mechanism involved in viral interference in Drosophila and Aedes is not dependent on the up-regulation of the immune effectors examined, although it cannot be excluded that immune priming in the heterologous mosquito host might enhance the virus interference trait.

Analysis of cluster-randomized test-negative designs: cluster-level methods.

A cluster-randomized test-negative design that includes randomization of the intervention at a group level is introduced that is based on the randomization distribution induced by permuting intervention assignment across two sets of randomly selected clusters.

Allocation techniques for balance at baseline in cluster randomized trials: a methodological review

The advantages and limitations of different allocation techniques, including stratification, matching, minimization, and covariate-constrained randomization are reviewed as they pertain to C-RCTs to provide investigators with guidance for choosing the best allocation technique for their trial.

Development of a novel ozone- and photo-stable HyPer5 red fluorescent dye for array CGH and microarray gene expression analysis with consistent performance irrespective of environmental conditions

HyPer5 is a red fluorescent dye that behaves functionally similar to Cy5 except in stability to ozone and light, and is demonstrated to be resistant to ozone at up to 300 ppb, levels significantly higher than commonly observed during summer months.