Efficacy of Probiotics in Irritable Bowel Syndrome: A Meta-Analysis of Randomized, Controlled Trials

  title={Efficacy of Probiotics in Irritable Bowel Syndrome: A Meta-Analysis of Randomized, Controlled Trials},
  author={Shekoufeh Nikfar and Roja Rahimi and Fatemeh Rahimi and Saeed Derakhshani and M. Abdollahi},
  journal={Diseases of the Colon \& Rectum},
PurposeThis study was designed to evaluate whether probiotics improve symptoms in patients with irritable bowel syndrome.MethodsPubMed, Embase, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials were searched for studies that investigated the efficacy of probiotics in the management of irritable bowel syndrome. Clinical improvement was the key outcome of interest. Data were searched within the time period of 1966 through September 2007.ResultsEight randomized, placebo… 

Therapeutic effects of Lactobacillus in treating irritable bowel syndrome: a meta-analysis.

Compared with the placebo, Lactobacillus treatment was found to be associated with a significantly higher rate of treatment responders in the overall population with IBS, without any side effects.

Effectiveness Of Probiotics In Irritable Bowel Syndrome: A Systematic Review With Meta-Analysis.

Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis.

Probiotics reduce pain and symptom severity scores and demonstrate the beneficial effects of probiotics in IBS patients in comparison with placebo.

The place of antibiotics in management of irritable bowel syndrome: a systematic review and meta-analysis

Although antibiotics have a statistically significant effect on IBS and bloating, given the evidence for the presence of publication bias, methodological variability of the trials and lack of a precise scientific explanation for the role of bacterial overgrowth in the pathophysiology of IBS, use of antibiotics on a regular basis in IBS patients is not recommended.

Efficacy of probiotics in irritable bowel syndrome: a meta-analysis of randomized, controlled trials.

Searching PubMed, EMBASE, Scopus, Web of Science and Cochrane Central Register of Controlled Trials were searched from 1996 to September 2007. Search terms were reported. Additional studies were

Efficacy of tricyclic antidepressants in irritable bowel syndrome: a meta-analysis.

It is concluded that low dose TCAs exhibit clinically and statistically significant control of IBS symptoms.

Effectiveness and Safety of Probiotics for Patients with Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of 10 Randomized Controlled Trials

The low-to-very low certainty evidence suggests that probiotics might improve the stool consistency of patients with IBS-C and increase the number of Bifidobacteria and Lactobacilli in feces with good safety, however, more high-quality studies with large samples are needed to verify the findings.

A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome.

The efficacy and tolerability of mebeverine in irritable bowel syndrome is mostly well tolerated with no significant adverse effects; however, its efficacy in global improvement of IBS is not statistically significant.

Efficacy of double-coated probiotics for irritable bowel syndrome: a randomized double-blind controlled trial

The result implies that dual-coating layers of probiotic supplement can be a candidate for treatment of diarrhea-predominant irritable bowel syndrome and shows significant negative correlation between Bifidobacterium and urgency of defecation.

Probiotics and Irritable Bowel Syndrome

Some recent, randomized, controlled studies attest to the efficacy of some probiotics in alleviating individual IBS symptoms while selected strains have a more global impact, and evidence for long-term efficacy is also beginning to emerge though more studies are needed in this regard.



Bacterial supplementation in the irritable bowel syndrome. A randomised double-blind placebo-controlled crossover study.

  • M. O'SullivanC. O'Morain
  • Medicine
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2000

Irritable bowel syndrome and probiotics: from rationale to clinical use

Animal research will continue to identify novel targets and elucidate the mechanisms of action of probiotics, thus providing a rational basis for their use in irritable bowel syndrome, although clinical evidence is not yet sufficient to enable clear guidelines to be designed.

A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome

LP299V seems to have a beneficial effect in patients with IBS, and further studies on larger cohorts of patients and with longer duration of therapy are required in order to establish the place of L. plantarum in the treatment of IBS.

Probiotics in The Treatment of Irritable Bowel Syndrome

  • A. Saggioro
  • Medicine
    Journal of clinical gastroenterology
  • 2004
In conclusion, short-term therapy with Lactobacillus PlantarumLP0 1 and Bifidocterium Breve BR0 may be considered a promising approach to the therapy for IBS.

Meta-analysis of probiotics for the prevention of traveler's diarrhea.

  • L. Mcfarland
  • Medicine
    Travel medicine and infectious disease
  • 2007

A Meta-Analysis of Antibiotic Therapy for Active Ulcerative Colitis

It is suggested that adjunctive antibacterial therapy is effective for induction of clinical remission in ulcerative colitis.

Bulking agents, antispasmodic and antidepressant medication for the treatment of irritable bowel syndrome.

The primary objective of this review was to evaluate the efficacy of bulking agents, antispasmodic and antidepressant medication for the treatment of IBS patients over 12 years of age.

Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date

  • E. QuigleyB. Flourié
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2007
The clear delineation of a post‐infective variety of irritable bowel syndrome (IBS), as well as the description, in a number of studies, of evidence of low‐grade inflammation and immune activation in IBS, suggest a role for a dysfunctional relationship between the indigenous flora and the host in Ibs and provide a clear rationale for the use of probiotics in this disorder.