Efficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation: Systematic Review and Meta-analysis

@article{Ford2014EfficacyOP,
  title={Efficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation: Systematic Review and Meta-analysis},
  author={Alexander Charles Ford and Eamonn M M Quigley and Brian E. Lacy and Anthony J Lembo and Yuri A Saito and Lawrence R. Schiller and Edy E. Soffer and Brennan M. R. Spiegel and Paul Moayyedi},
  journal={The American Journal of Gastroenterology},
  year={2014},
  volume={109},
  pages={1547-1561}
}
OBJECTIVES:Irritable bowel syndrome (IBS) and chronic idiopathic constipation (CIC) are functional bowel disorders. Evidence suggests that disturbance in the gastrointestinal microbiota may be implicated in both conditions. We performed a systematic review and meta-analysis to examine the efficacy of prebiotics, probiotics, and synbiotics in IBS and CIC.METHODS:MEDLINE, EMBASE, and the Cochrane Controlled Trials Register were searched (up to December 2013). Randomized controlled trials (RCTs… 

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