Efficacy of Oral Collagen in Joint Pain - Osteoarthritis and Rheumatoid Arthritis

@article{Woo2017EfficacyOO,
  title={Efficacy of Oral Collagen in Joint Pain - Osteoarthritis and Rheumatoid Arthritis},
  author={T Woo and Lilian Lau and N Cheng and Ping Keung Chan and Keith Tan and A Gardner},
  journal={Journal of Arthritis},
  year={2017},
  volume={6},
  pages={1-4}
}
Introduction: Joint pain is one of the most common types of chronic pain. Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two leading causes of joint pain and there are currently no prophylactic or curative treatments available. Oral collagen has been implicated in providing a potential means to treat arthritis. This review article aims to identify, evaluate and summarize the results of published animal and human clinical trials related to oral collagen in the treatment of joint pain… 

Tables from this paper

The Therapeutic Potential of Targeted Nanoparticulate Systems to Treat Rheumatoid Arthritis

The role of various nanoparticulate systems for passive and active targeting of RA has been reviewed and the current practices in the typical and novel nanosystems to improve the quality of life in RA patients are summarized.

The effects of collagen peptides on muscle damage, inflammation and bone turnover following exercise: a randomized, controlled trial

CP had moderate benefits for the recovery of CMJ and muscle soreness but had no influence on inflammation and bone collagen synthesis.

Title : The effects of collagen peptides on muscle damage , inflammation and bone 1 turnover following exercise : a randomized , controlled trial 2 3 Running Head : Collagen peptides and exercise recovery

CP had moderate benefits for the recovery of CMJ and muscle soreness but had no influence on inflammation and bone collagen synthesis.

Artificial intelligence-assisted development of in situ forming nanoparticles for arthritis therapy via intra-articular delivery

The optimized formulation, exhibiting a nano-sized particle size with a dense core, showed significant improvement in the histopathological findings compared to both the oral solution and the placebo, and demonstrated their effectiveness in piroxicam delivery for RA treatment.

Human Chondrocyte Activation by Toxins From Premolis semirufa, an Amazon Rainforest Moth Caterpillar: Identifying an Osteoarthritis Signature

Results suggest that components of Premolis semirufa hair have strong inflammatory potential and are able to induce cartilage degradation and ECM remodeling, promoting a disease with an osteoarthritis signature.

Prevalence and factors associated with joint pain in Nepal: findings from a countrywide cross-sectional STEPS survey

The results showed a high prevalence of joint pain in Nepal, which warrants the need for health policies directed to prevention, treatment and rehabilitation for people affected by chronic musculoskeletal conditions addressing related disabilities and loss of work in Nepal.

A Review of the Literature Relating to Collagen Hydrolysate and Its Potential Clinical Applications

  • M. Wakeman
  • Biology
    Journal of Advances in Medicine and Medical Research
  • 2021
Manufacturing processes employed to typically produce hydrolysed collagen are examined, studies examining bioavailability, metabolism and likely health benefits as well as potential clinical applications as a nutraceutical are evaluated.

Fish Collagen and its Applications in Food and Pharmaceutical Industry : A Review

Marine collagen has gained immense attention in the recent past as an appropriate alternative to mammalian collagen and finds wide application in food, pharmaceutical and biomedical industries.

Biopolymer nanofibrils: structure, modeling, preparation, and applications.

References

SHOWING 1-10 OF 29 REFERENCES

Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial.

Positive effects were observed with C II at the lowest dosage tested, and the presence of serum antibodies to CII at baseline may predict response to therapy.

Effects of oral administration of type II collagen on rheumatoid arthritis.

Clinical efficacy of an oral tolerization approach for rheumatoid arthritis is demonstrated and a decrease in the number of swollen joints and tender joints occurred in subjects fed chicken type II collagen for 3 months but not in those that received a placebo.

Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial

The results indicate that UC-II treatment was more efficacious resulting in a significant reduction in all assessments from the baseline at 90 days; whereas, this effect was not observed in G+C treatment group.

A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis

CCII is effective in the treatment of RA and is safe for human consumption and exerts its beneficial effects by controlling inflammatory responses through inducing oral tolerance in RA patients.

Role of collagen hydrolysate in bone and joint disease.

  • R. Moskowitz
  • Medicine
    Seminars in arthritis and rheumatism
  • 2000
Collagen hydrolysate is of interest as a therapeutic agent of potential utility in the treatment of osteoarthritis and osteoporosis, and its high level of safety makes it attractive as an agent for long-term use in these chronic disorders.

A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis.

CCII is effective in the treatment of RA, and the incidence of adverse events of CCII is lower than that of MTX, which is well tolerated.

A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis.

The study demonstrated that collagen peptides are potential therapeutic agents as nutritional supplements for the management of osteoarthritis and maintenance of joint health.

Adjuvant arthritis: immunopathological and hyperalgesic features.

The above studies further corroborate the similarities between the immunopathological and hyperalgesic features of human rheumatoid arthritis and adjuvant disease and may result in the ability to evaluate new classes of immunoregulating agents.

Adjuvant arthritis: immunopathological and hyperalgesic features.

The adjuvant rat has been found useful as a pain model capable of detecting the analgesic properties of both central and the newer peripheral analgesics, and further corroborate the similarities between the immunopathological and hyperalgesic features of human rheumatoid arthritis and adjUvant disease.