Efficacy of Off-Label Topical Treatments for the Management of Androgenetic Alopecia: A Review

@article{Gupta2019EfficacyOO,
  title={Efficacy of Off-Label Topical Treatments for the Management of Androgenetic Alopecia: A Review},
  author={Aditya K. Gupta and Rachel R Mays and Sarah G. Versteeg and Neil H. Shear and Vincent Piguet and Bianca Maria Piraccini},
  journal={Clinical Drug Investigation},
  year={2019},
  volume={39},
  pages={233-239}
}
Androgenetic alopecia (AGA) is characterized by non-scarring follicle miniaturization. Despite the success of approved therapies, commonly reported side effects and the need for continual use has led to the investigation of alternative therapies. The aim of this paper is to critically review the success of off-label, topical monotherapies for treatment of AGA in men. A literature search was conducted to obtain randomized, controlled and blinded studies that investigated off-label, topical… 
4 Citations
A randomized, single‐blinded, vehicle‐controlled study of a topical active blend in the treatment of androgenetic alopecia
TLDR
A new topical active blend is effective in the treatment of AGA, with high degree of patients' satisfaction, improvement of quality of life, and an excellent safety profile, Thus, it may represent a useful alternative therapeutic approach for AGA.
Exploring the potential of minoxidil tretinoin liposomal based hydrogel for topical delivery in the treatment of androgenic alopecia
TLDR
Overall developed liposome loaded hydrogel system showed potential for effective and simultaneous delivery of both the drugs.
Novel iron oxide nanocarriers loading finasteride or dutasteride: enhanced skin penetration for topical treatment of alopecia.
TLDR
Iron nanocarriers present a desirable visual characteristic, as the dark color aspect might instantly help disguise scarce hair follicle areas, and suggest the nanoformulations are highly promising for alopecia therapies.

References

SHOWING 1-10 OF 26 REFERENCES
Pilot study of a novel treatment for androgenetic alopecia using enriched cell culture medium: clinical trials.
TLDR
CCM was found effective in treating androgenetic alopecia in men and induced cessation of hair loss, increased rate of hair growth and appearance of new hair.
Topical valproic acid increases the hair count in male patients with androgenetic alopecia: A randomized, comparative, clinical feasibility study using phototrichogram analysis
  • S. Jo, Hyoseung Shin, +5 authors O. Kwon
  • Medicine
    The Journal of dermatology
  • 2014
TLDR
Topical VPA increased the total hair counts of the authors' patients; therefore, it is a potential treatment option for androgenetic alopecia (AGA) and should be considered for further studies.
Treatment of androgenetic alopecia with a 7.5% herbal preparation
TLDR
A group of 24 healthy male subjects under the age of 55 years with stage III-IV androgenetic alopecia were enrolled in a randomized double-blind parallel-group vehicle-controlled study lasting 48 weeks.
Topical adenosine increases the proportion of thick hair in Caucasian men with androgenetic alopecia
TLDR
Adenosine is effective in increasing the proportion of thick hair in Caucasian men with AGA as well as in Japanese men and women.
The effectiveness of the hair-restorer "Dabao" in males with alopecia androgenetica. A clinical experiment.
TLDR
It appears from the study that, although the cosmetic effect over 6 months is modest, Dabao does have a certain effect on the growth of nonvellus hair.
Transdermal viprostol in the treatment of male pattern baldness.
TLDR
Viprostol is not an effective hair growth promoter in androgenetic alopecia and nonvellus target area hair counts declined in all three treatment groups at the end of the 6-month study.
A mouse model of androgenetic alopecia.
TLDR
The hypothesis that androgen-mediated hair loss is AR dependent and suggest that AR and beta-catenin mediate this effect are supported and can now be used to test new therapeutic agents for the treatment of AGA, accelerating the drug discovery process.
Topical fulvestrant solution has no effect on male and postmenopausal female androgenetic alopecia: results from two randomized, proof‐of‐concept studies
TLDR
A topical formulation of fulvestrant was developed for the potential treatment of androgenetic alopecia based on preclinical studies in mice in which topical fulvestant caused telogen hair follicles to enter anagen, thereby causing hair growth.
Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent.
TLDR
Procyanidin B-2 therapy shows potential as a safe and promising cure for male pattern baldness after sequential use for 6 months and is significantly greater than that of the placebo control group subjects.
New Insight Into the Pathophysiology of Hair Loss Trigger a Paradigm Shift in the Treatment Approach.
TLDR
Research points to similar dysregulation of intrinsic signaling pathways within follicle physiology that span the hair loss disorder spectrum - with a common inflammatory component identified in most hair loss pathogenesis, including that of androgenetic alopecia (AGA).
...
1
2
3
...