Efficacy of Multivitamin/mineral Supplementation to Reduce Chronic Disease Risk: A Critical Review of the Evidence from Observational Studies and Randomized Controlled Trials

  title={Efficacy of Multivitamin/mineral Supplementation to Reduce Chronic Disease Risk: A Critical Review of the Evidence from Observational Studies and Randomized Controlled Trials},
  author={Giana Angelo and Victoria J. Drake and Balz Frei},
  journal={Critical Reviews in Food Science and Nutrition},
  pages={1968 - 1991}
We reviewed recent scientific evidence regarding the effects of multivitamin/mineral (MVM) supplements on risk of chronic diseases, including cancer, cardiovascular disease, and age-related eye diseases. Data from randomized controlled trials (RCTs) and observational, prospective cohort studies were examined. The majority of scientific studies investigating the use of MVM supplements in chronic disease risk reduction reported no significant effect. However, the largest and longest RCT of MVM… 

Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis

A systematic review and meta-analysis of clinical trials and prospective cohort studies demonstrates that MVM supplementation does not improve cardiovascular outcomes in the general population.

The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study

It is demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control, and had significantly reduced risks of elevated glucose and low HDL-C.

Effects of Nutrition Intervention on Total and Cancer Mortality: 25-Year Post-trial Follow-up of the 5.25-Year Linxian Nutrition Intervention Trial

Multiyear nutrition intervention is unlikely to have a meaningful effect on mortality more than a decade after supplementation ends, even in a nutritionally deprived population.

Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.

People taking antioxidant vitamins were less likely to progress to late AMD and low-certainty evidence from one study of 110 people suggested higher quality of life scores and a lower risk of losing 3 or more lines of visual acuity in treated people.

Effects of Oral Multi-Vitamin Multi-Mineral Supplement Formulations on Laboratory Outcomes and Quality of Life: A Quasi-Experimental Study

The supplements of MVMM in capsule formulation increased the serum levels of some micronutrients to a higher extent than that of granule formulation to investigate the changes in laboratory parameters and the quality of life among individuals who received different MVMM formulations.

Clinical and Vitamin Response to a Short‐Term Multi‐Micronutrient Intervention in Brazilian Children and Teens: From Population Data to Interindividual Responses

Elastic net penalized regression models are identified, and significantly predict response to intervention on the basis of multiple vitamin/clinical baseline measures, a step toward developing recommendations for optimizing vitamin levels and health parameters for individuals.

Use of Dietary Supplements Improved Diet Quality But Not Cardiovascular and Nutritional Biomarkers in Socioeconomically Diverse African American and White Adults

There were no significant differences between the population proportions with inadequate or excessive blood levels for any biomarkers examined and if supplements provided beneficial effects to micronutrient diet quality and nutritional and cardiovascular biomarkers.



Clinical trials and observational studies to assess the chronic disease benefits and risks of multivitamin-multimineral supplements.

  • R. Prentice
  • Medicine
    The American journal of clinical nutrition
  • 2007
The data are not compelling concerning a role for MVMs in preventing cancer or cardiovascular disease morbidity or mortality, although some interesting leads merit further evaluation.

Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial.

Among this population of US male physicians, taking a daily multivitamin did not reduce major cardiovascular events, MI, stroke, and CVD mortality after more than a decade of treatment and follow-up.

Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial.

In this large prevention trial of male physicians, daily multivitamin supplementation modestly but significantly reduced the risk of total cancer.

Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force

Limited evidence supports any benefit from vitamin and mineral supplementation for the prevention of cancer or CVD.

The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals.

After 7.5 years, low-dose antioxidant supplementation lowered total cancer incidence and all-cause mortality in men but not in women, suggesting that supplementation may be effective in men only because of their lower baseline status of certain antioxidants, especially of beta carotene.

Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial

Routine multivitamin and multimineral supplementation of older people living at home does not affect self reported infection related morbidity and quality of life is not affected.

Multivitamin/Mineral supplements and prevention of chronic disease: executive summary.

The Johns Hopkins University Evidence-based Practice Center (EPC) reviewed and synthesized the published literature on four Key Questions, finding that concurrent ingestion of several nutrients may result in synergistic, antagonistic, or threshold effects as compared to a single nutrient.

Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: a randomized controlled trial.

Neither daily multivitamin-mineral supplementation at physiological dose nor 200 mg of vitamin E showed a favorable effect on incidence and severity of acute respiratory tract infections in well-nourished noninstitutionalized elderly individuals.

Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: a randomized controlled trial

The results suggest that 6 mg of lutein supplementation in combination with other antioxidants is not beneficial for this group, and further work is required to establish optimum dosage levels.

Multivitamin use and risk of cancer and cardiovascular disease in the Women's Health Initiative cohorts.

The Women's Health Initiative study provided convincing evidence that multivitamin use has little or no influence on the risk of common cancers, CVD, or total mortality in postmenopausal women.