Efficacy of Memantine in Schizophrenic Patients: A Systematic Review

  title={Efficacy of Memantine in Schizophrenic Patients: A Systematic Review},
  author={Giuseppe Di Iorio and Gaia Baroni and Marco Lorusso and Chiara Montemitro and Maria Chiara Spano and Massimo di Giannantonio},
  booktitle={Journal of amino acids},
Several evidences support the hypothesis that glutamatergic dysfunction may be implicated in the pathogenesis of schizophrenia and in the last few years great interest has been focused on the role of the N-methyl-D-aspartate receptor (NMDAR). Glutamate is the main excitatory neurotransmitter in human CNS and it plays a prominent role in synaptic plasticity, learning, and memory and other cognitive functions. Increasing interest in memantine add-on therapy in schizophrenic patients with negative… CONTINUE READING
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