Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.

@article{Maude2015EfficacyOJ,
  title={Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.},
  author={Shannon L Maude and Sibasish Dolai and Cristina Delgado-Martin and Tiffaney L. Vincent and Alissa K. Robbins and Arthavan Selvanathan and Theresa Ryan and Junior W Hall and Andrew Craig Wood and Sarah K Tasian and Stephen P Hunger and Mignon L Loh and Charles G Mullighan and Brent L Wood and Michelle L Hermiston and Stephan A. Grupp and Richard B. Lock and David T Teachey},
  journal={Blood},
  year={2015},
  volume={125 11},
  pages={
          1759-67
        }
}
Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a recently described subtype of T-ALL characterized by a unique immunophenotype and genomic profile, as well as a high rate of induction failure. Frequent mutations in cytokine receptor and Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways led us to hypothesize that ETP-ALL is dependent on JAK/STAT signaling. Here we demonstrate aberrant activation of the JAK/STAT pathway in ETP-ALL… CONTINUE READING
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HOXA genes are included in genetic and biologic 1766 MAUDE et al BLOOD, 12 MARCH 2015 x VOLUME 125, NUMBER 11 For personal use

J Soulier, E Clappier, JM Cayuela
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  • 2015

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