Efficacy of Hydroxocobalamin for the Treatment of Acute Cyanide Poisoning in Adult Beagle Dogs

@article{Borron2006EfficacyOH,
  title={Efficacy of Hydroxocobalamin for the Treatment of Acute Cyanide Poisoning in Adult Beagle Dogs},
  author={S. Borron and M. Stonerook and F. Reid},
  journal={Clinical Toxicology},
  year={2006},
  volume={44},
  pages={15 - 5}
}
Introduction. The efficacy of hydroxocobalamin for acute cyanide poisoning was compared with that of saline vehicle in dogs. Methods. Anesthetized adult beagle dogs were administered potassium cyanide (0.4 mg/kg/min, IV) until 3 min after the onset of apnea. Hydroxocobalamin (75 mg/kg [n = 19] or 150 mg/kg [n = 18], IV) or saline vehicle [n = 17] was then infused over 7.5 min while animals were ventilated with 100% oxygen, which was stopped after 15 min. Results. In vehicle-treated animals… Expand
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TLDR
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TLDR
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TLDR
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