Efficacy of FCE 22101 compared with imipenem and with gentamicin plus metronidazole in the treatment of experimental intra-abdominal infections in rats.


A reproducible experimental model of intra-abdominal infection in rats has been created to simulate infection in humans. Preoperatively, the rats were fed with lean ground beef for two weeks in order to change the intestinal microflora into a flora similar to that found in humans. A 1-cm segment of ileum was isolated on its vascular pedicle. The intestine… (More)