Efficacy of Epidural Perineural Injections With Autologous Conditioned Serum for Lumbar Radicular Compression: An Investigator-Initiated, Prospective, Double-Blind, Reference-Controlled Study

@article{Becker2007EfficacyOE,
  title={Efficacy of Epidural Perineural Injections With Autologous Conditioned Serum for Lumbar Radicular Compression: An Investigator-Initiated, Prospective, Double-Blind, Reference-Controlled Study},
  author={Cordelia Becker and Stefan Heidersdorf and Sascha Drewlo and Sonja Zirke de Rodriguez and J. Kr{\"a}mer and Roland Ernst Willburger},
  journal={Spine},
  year={2007},
  volume={32},
  pages={1803-1808}
}
Study Design. Prospective, double-blind, reference-controlled, investigator-initiated, single center. Objective. To evaluate the efficacy of Autologous Conditioned Serum (ACS; Orthokine) for the treatment of lumbar radicular compression in comparison to triamcinolone. Summary of Background Data. Evidence from animal studies indicates that cytokines such as interleukin-1 play a decisive role in the pathophysiology of lumbar radiculopathy. ACS is enriched in the interleukin-1 receptor antagonist… 

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