Efficacy of Desmodium gangeticum extract and its fractions against experimental visceral leishmaniasis.

@article{Singh2005EfficacyOD,
  title={Efficacy of Desmodium gangeticum extract and its fractions against experimental visceral leishmaniasis.},
  author={Navjeevanjot Singh and Pushpesh Kumar Mishra and Aruna Kapil and Kamal Ram Arya and Rakesh N. Maurya and Anuradha Dube},
  journal={Journal of ethnopharmacology},
  year={2005},
  volume={98 1-2},
  pages={
          83-8
        }
}
Crude ethanolic extract of Indian medicinal plant, Desmodium gangeticum (A001) and its three fractions-hexane (F002), n-butanol (F003) and aqueous (F004) were evaluated chemoprophylactically and chemotherapeutically against experimental visceral leishmaniasis in hamsters. Ethanolic extract showed 41.2+/-5.3% inhibition of parasite multiplication when administered at a dose of 250 mg/kgx2 on day -7 and +7 of Leishmania donovani challenge. Its n-butanol fraction exhibited better efficacy than the… CONTINUE READING
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