Efficacy of Curosurf in a rat model of acute respiratory distress syndrome.

@article{Helden1998EfficacyOC,
  title={Efficacy of Curosurf in a rat model of acute respiratory distress syndrome.},
  author={Herman P M van Helden and Willem C Kuijpers and P E Langerwerf and Ramon C. J. Langen and Henk P Haagsman and Pieter L. B. Bruijnzeel},
  journal={The European respiratory journal},
  year={1998},
  volume={12 3},
  pages={533-9}
}
Curosurf, a natural lung surfactant, is considered a potential candidate for improving the treatment of acute respiratory distress syndrome (ARDS). To investigate this in a rat model of early-stage ARDS, Curosurf (62.5, 125 or 250 mg x kg(-1)) was administered by intratracheal bolus at 10 or 24 h following an intratracheal lipopolysaccharide (LPS; 1.6 mg x kg(-1)) challenge. Survival, respiratory frequency (fR), lung wet weight (LWW), total protein and cell differentiation in bronchoalveolar… CONTINUE READING